Evidence map›Paper›PMID 34625828›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

Combination of terbium-161 with somatostatin receptor antagonists-a potential paradigm shift for the treatment of neuroendocrine neoplasms.

Francesca Borgna, Stephanie Haller, Josep M Monné Rodriguez, Mihaela Ginj, Pascal V Grundler, Jan Rijn Zeevaart, Ulli Köster, Roger Schibli, Nicholas P van der Meulen, Cristina Müller

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 99 citations in OpenAlex.

  1. Targeted βJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Trial
  2. Cancer theranostics.Nature reviews. Cancer · 2026
    Review
  3. Review
  4. Review
  5. Evaluation of treatment efficacy of theEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  6. Review
  7. Organ and tumor dosimetry of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  8. Article
  9. [EJNMMI research · 2026
    Article
  10. Article
  11. Article
  12. Preclinical Evaluation of 5T4-Targeted [Journal of medicinal chemistry · 2026
    Article
  13. Review
  14. Article
  15. Comparative theranostic efficacy ofEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  16. Article
  17. [Pharmaceutics · 2026
    Article
  18. Review
  19. Article
  20. Head-to-head comparison of [EJNMMI research · 2026
    Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Francesca BorgnaCenter for Radiopharmaceutical Sciences, ETH-PSI-USZ, Paul Scherrer Institute, 5232, Villigen-PSI, Switzerland.
Stephanie HallerCenter for Radiopharmaceutical Sciences, ETH-PSI-USZ, Paul Scherrer Institute, 5232, Villigen-PSI, Switzerland.
Josep M Monné RodriguezLaboratory for Animal Model Pathology, Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, 8057, Zurich, Switzerland.
Mihaela GinjThe Joint Department of Medical Imaging, University Health Network, 200 Elizabeth St, Toronto, ON, M5G 2C4, Canada.
Pascal V GrundlerCenter for Radiopharmaceutical Sciences, ETH-PSI-USZ, Paul Scherrer Institute, 5232, Villigen-PSI, Switzerland.
Jan Rijn ZeevaartSouth African Nuclear Energy Corporation (Necsa), Pelindaba, Brits, 0240, South Africa.
Ulli KösterInstitut Laue-Langevin, 38042, Grenoble, France.
Roger SchibliCenter for Radiopharmaceutical Sciences, ETH-PSI-USZ, Paul Scherrer Institute, 5232, Villigen-PSI, Switzerland.
Nicholas P van der MeulenCenter for Radiopharmaceutical Sciences, ETH-PSI-USZ, Paul Scherrer Institute, 5232, Villigen-PSI, Switzerland.
Cristina MüllerCenter for Radiopharmaceutical Sciences, ETH-PSI-USZ, Paul Scherrer Institute, 5232, Villigen-PSI, Switzerland. cristina.mueller@psi.ch.
Paul Scherrer Institute · CHETH Zurich · CHInstitut Laue-Langevin · FRSouth African Nuclear Energy Corporation (South Africa) · ZAUniversity Health Network · CAUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe β

methodsThe capability of the

resultsIn vitro, [

conclusionThe use of membrane-localizing DOTA-LM3 was beneficial and profited from the short-ranged electrons emitted by terbium-161. Based on these preclinical data, [

Indexed as

Neuroendocrine TumorsReceptors, SomatostatinAnimalsHumansMiceOctreotideRadioisotopesTerbiumTissue DistributionOctreotideRadioisotopesReceptors, SomatostatinTerbiumTerbium-161Auger electronsNENPRRTRadionuclide therapySSTR antagonistsTerbium-161

Identifiers

PMID34625828
PMCPMC8921065
OpenAlexW3203242711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.