ArticleNature structural & molecular biology2021
The structural basis of PTEN regulation by multi-site phosphorylation.
Open access · greenAbstract read
In one paragraph
Article in Nature structural & molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Aberrant Energy Metabolism in Tumors and Potential Therapeutic Targets.Genes, chromosomes & cancer · 2024Pooled it
- G0 or no-G0: phosphatase control of quiescence and cell cycle entry.Biochemical Society transactions · 2026Review
- Structural and mechanistic basis of mTORC2 activation of protein kinase AKT/PKB.The Biochemical journal · 2026Review
- TSPAN32 as a biomarker associated with radiotherapy and immune microenvironment remodeling in lung adenocarcinoma.Frontiers in oncology · 2026Article
- Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome.Disease models & mechanisms · 2026Article
- Prenatal Delivery of HIF-1α siRNA Using Transferrin-Modified Lipid Nanoparticles Alleviates Hypoxia-Induced Neurodevelopmental Abnormalities via PTEN/PI3K/AKT Signaling.International journal of nanomedicine · 2026Article
- RNA and ChIP-sequencing analysis reveals SOX3 suppresses antiviral innate immunity through the AKT1-PTEN signaling axis.Virologica Sinica · 2025Article
- Peroxiredoxin 4 as a switch regulating PTEN/AKT axis in alveolar macrophages activation.Signal transduction and targeted therapy · 2025Article
- Global comparative structural analysis of responses to protein phosphorylation.Nature communications · 2025Article
- Elucidating PTEN conformational dynamics and phosphatase regulation via integrative modeling and mutation prediction.Structure (London, England : 1993) · 2025Article
- Structural biology at the National Synchrotron Light Source II.Journal of synchrotron radiation · 2025Article
- Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer.Life (Basel, Switzerland) · 2025Review
- Post-Translational Modification of PTEN Protein: Quantity and Activity.Oncology reviews · 2024Review
- Cancer and Autism: How PTEN Mutations Degrade Function at the Membrane and Isoform Expression in the Human Brain.Journal of molecular biology · 2023Article
- The long non-coding RNA keratin-7 antisense acts as a new tumor suppressor to inhibit tumorigenesis and enhance apoptosis in lung and breast cancers.Cell death & disease · 2023Article
- Semisynthetic Approach to the Analysis of Tumor Suppressor PTEN Ubiquitination.Journal of the American Chemical Society · 2023Article
- TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN.Signal transduction and targeted therapy · 2023Article
- Nuclear PTEN's Functions in Suppressing Tumorigenesis: Implications for Rare Cancers.Biomolecules · 2023Review
- Mutation of S461, in the GOLGA3 phosphorylation site, does not affect mouse spermatogenesis.PeerJ · 2023Article
- Regulatory mechanisms triggered by enzyme interactions with lipid membrane surfaces.Frontiers in molecular biosciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 1 country.
Daniel R Dempsey *Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6104-0805
Thibault Viennet *Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5349-0179
Reina IwaseDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Eunyoung ParkDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Stephanie HenriquezDepartment of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Zan ChenDepartment of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Jeliazko R JeliazkovDepartments of Chemical and Biomolecular Engineering and Biophysics, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-4249-1955
Brad A PalanskiDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Kim L PhanDepartments of Medicine, Oncology, and Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Paul CooteDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Jeffrey J GrayDepartments of Chemical and Biomolecular Engineering and Biophysics, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-6380-2324
Michael J EckDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Sandra B GabelliDepartments of Medicine, Oncology, and Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, USA. gabelli@jhmi.edu.ORCID http://orcid.org/0000-0003-1205-5204
Haribabu ArthanariDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. hari@hms.harvard.edu.ORCID http://orcid.org/0000-0002-7281-1289
Philip A ColeDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. pacole@bwh.harvard.edu.ORCID http://orcid.org/0000-0001-6873-7824
Johns Hopkins University · USHarvard University · USBrigham and Women's Hospital · US
Funding
OverallP41EB002026 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRIFFIN, ROBERT GUY · 2003 to 2018
$17.9MPROGRAM IN MOLECULAR BIOPHYSICST32GM008403 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BARRICK, DOUGLAS E. · 1990 to 2019
$13.5MChemical Approaches to Protein PhosphorylationR01CA074305 · NCI · JOHNS HOPKINS UNIVERSITY · PI COLE, PHILIP A · 2002 to 2025
$8.0MStructure, mechanism, and pharmacology of BRAF and its partners in the RAS/RAF/MAP kinase pathwayR35CA242461 · NCI · DANA-FARBER CANCER INST · PI ECK, MICHAEL J · 2019 to 2025
$7.4MPrediction of the Structure of Therapeutic Antibodies with their AntigensR01GM078221 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GRAY, JEFFREY J · 2006 to 2020
$4.0MThe Chemistry-Biology Interface Program at Johns Hopkins UniversityT32GM080189 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROKITA, STEVEN E · 2008 to 2022
$3.5MNMR Fingerprinting: Leveraging optimal control pulse design, tailored isotope labeling, and machine learning to study intractable proteinsR01GM136859 · NIGMS · DANA-FARBER CANCER INST · PI ARTHANARI, HARIBABU · 2020 to 2024
$2.4MStructural biology and drug discovery targeting oncogenic EGFR and BRAF kinasesR50CA221830 · NCI · DANA-FARBER CANCER INST · PI PARK, EUNYOUNG · 2017 to 2021
$942kMolecular Mechanisms of PTEN and USP7 RegulationK99GM130961 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMPSEY, DANIEL R. · 2019 to 2020
$200kStructural and Functional Analysis of the Post-translational Modifications of PTEN and MKP-1F32GM120855 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI DEMPSEY, DANIEL R. · 2016 to 2017
$113kNCI NIH HHS R01 CA074305NCI NIH HHS R35 CA242461NCI NIH HHS R50 CA221830NIBIB NIH HHS P41 EB002026NIGMS NIH HHS F32 GM120855NIGMS NIH HHS K99 GM130961NIGMS NIH HHS R01 GM078221NIGMS NIH HHS R01 GM136859NIGMS NIH HHS T32 GM008403NIGMS NIH HHS T32 GM080189
Abstract
Phosphatase and tensin homolog (PTEN) is a phosphatidylinositol-3,4,5-triphosphate (PIP
Indexed as
AnimalsCiona intestinalisCrystallography, X-RayFluorescence PolarizationHumansMagnetic Resonance SpectroscopyMolecular Docking SimulationPhosphorylationPTEN PhosphohydrolasePTEN PhosphohydrolasePTEN protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.