ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022
A three-factor model of common early onset psychiatric disorders: temperament, adversity, and dopamine.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Reimagining the Biopsychosocial Model: Transdiagnostic Factors to Precision Psychiatry.Biological psychiatry global open science · 2026Article
- Reimagining the biopsychosocial model: hierarchical mechanisms from transdiagnostic to precision psychiatry.Journal of psychiatry & neuroscience : JPN · 2026Review
- A Novel Diathesis-Stress Model of Comorbid Early Onset Psychiatric Disorders.medRxiv : the preprint server for health sciences · 2025Article
- A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [Alcohol, clinical & experimental research · 2025Article
- The impact of life events on NSSI among left-behind college students: the mediating role of PLEs and the moderating role of social support.Frontiers in psychology · 2025Article
- The influence of dopamine autoreceptors on temperament and addiction risk.Neuroscience and biobehavioral reviews · 2023Review
- Early cognitive comorbidities before disease onset: A common symptom towards prevention of related brain diseases?Heliyon · 2022Review
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 4 countries.
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Abstract
Commonly comorbid early onset psychiatric disorders might reflect the varying expression of overlapping risk factors. The mediating processes remain poorly understood, but three factors show some promise: adolescent externalizing traits, early life adversity, and midbrain dopamine autoreceptors. To investigate whether these features acquire greater predictive power when combined, a longitudinal study was conducted in youth who have been followed since birth. Cohort members were invited to participate based on externalizing scores between 11 to 16 years of age. At age 18 (age 18.5 ± 0.6 y.o.), 52 entry criteria meeting volunteers had a 90-min positron emission tomography scan with [
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Registered trials
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