Evidence map›Paper›PMID 34625583›Full record

ArticleScientific reports2021

GAS5 rs2067079 and miR-137 rs1625579 functional SNPs and risk of chronic hepatitis B virus infection among Egyptian patients.

Rania H Mahmoud, Enas Mamdouh Hefzy, Olfat G Shaker, Tarek I Ahmed, Noha K Abdelghaffar, Essam A Hassan, Amal A Ibrahim, Doaa Y Ali, Mohamed M Mohamed, Omayma O Abdelaleem

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Frontiers in immunology · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rania H MahmoudDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Enas Mamdouh HefzyDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum, 63514, Egypt. emh01@fayoum.edu.eg.
Olfat G ShakerDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Tarek I AhmedDepartment of Internal Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Noha K AbdelghaffarDepartment of Clinical Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Essam A HassanDepartment of Tropical Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Amal A IbrahimDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum, 63514, Egypt.
Doaa Y AliDepartment of Clinical Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Mohamed M MohamedDepartment of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Omayma O AbdelaleemDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Fayoum University · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis B virus (HBV) infection is a significant health issue worldwide.. We attempted to fulfill the molecular mechanisms of epigenetic and genetic factors associated with chronic HBV (CHBV). Expression levels of the lncRNA growth arrest-specific 5 (GAS5) and miR-137 and their corresponding SNPs, rs2067079 (C/T) and rs1625579 (G/T) were analyzed in 117 CHBV patients and 120 controls to investigate the probable association between these biomarkers and CHBV pathogenesis in the Egyptian population. Serum expression levels of GAS5 and miR-137 were significantly down-regulated in cases vs controls. Regarding GAS5 (rs2067079), the mutant TT genotype showed an increased risk of CHBV (p < 0.001), while the dominant CC was a protective factor (p = 0.004). Regarding miR-137 rs1625579, the mutant genotype TT was reported as a risk factor for CHBV (p < 0.001) and the normal GG genotype was a protective factor, p < 0.001. The serum GAS5 was significantly higher in the mutant TT genotype of GAS5 SNP as compared to the other genotypes (p = 0.007). Concerning miR-137 rs1625579, the mutant TT genotype was significantly associated with a lower serum expression level of miR-137 (p = 0.018). We revealed the dysregulated expression levels of GAS5 and miR-137 linked to their functioning SNPs were associated with CHBV risk and might act as potential therapeutic targets.

Indexed as

Hepatitis B, ChronicMicroRNAsRNA, Long NoncodingAdultBiomarkersEgyptFemaleGenetic Predisposition to DiseaseHepatitis BHumansMalePolymorphism, Single NucleotideBiomarkersGAS5 long non-coding RNA, humanMicroRNAsMIRN137 microRNA, humanRNA, Long Noncoding

Identifiers

PMID34625583
PMCPMC8501054
OpenAlexW3204213097

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.