ArticleThe European respiratory journal2022
Association of blood trihalomethane concentrations with asthma in US adolescents: nationally representative cross-sectional study.
Article in The European respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 27 citations in OpenAlex.
- Blood Trihalomethane Concentrations and Gestational Diabetes Mellitus: A Nationwide Cross-Sectional Study.Current medical science · 2026Article
- Disinfection Byproducts, Oxidative Stress, and Sleep Quality among Healthy Chinese Men.Environment & health (Washington, D.C.) · 2026Article
- Health risk assessment of disinfection by-products in drinking water on children and adolescents aged 6-17 in Ningbo city, China.Frontiers in public health · 2026Article
- Association of blood trihalomethane concentrations with diabetes mellitus in older adults in the US: a cross-sectional study of NHANES 2013-2018.Frontiers in endocrinology · 2024Article
- Pulmonary function in swimmers exposed to disinfection by-products: a narrative review.Frontiers in physiology · 2024Review
- Blood trihalomethane concentrations and allergic sensitization: A nationwide cross-sectional study.The Science of the total environment · 2023Article
- Blood volatile organic compounds associated with non-reversible and reversible airflow obstruction in US adults.The European respiratory journal · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundPopulation studies show that the use of swimming pools is associated with the risk of asthma and allergic diseases among children. Our objective was to explore the associations between blood trihalomethane (THM) concentrations and asthma among US adolescents, and assess to what extent the association is modified by active tobacco smoke exposure.
methodsWe included 2359 adolescents aged 12-19 years with measured blood concentrations of chloroform (trichloromethane (TCM)), bromodichloromethane (BDCM), dibromochloromethane (DBCM) and bromoform (tribromomethane (TBM)) from the National Health and Nutrition Examination Survey 2005-2012. Logistic regression models were fitted to assess the odds ratios for the association of blood THM concentrations (three or four categories) with the risk of self-reported current and ever (lifetime) asthma.
resultsBlood DBCM concentrations were associated with a higher risk of ever asthma among all adolescents (OR 1.54 (95% CI 1.07-2.21), comparing the extreme exposure categories). The relationship was stronger among adolescents exposed to tobacco smoke (OR 3.96 (95% CI 1.89-8.30), comparing the extreme exposure categories). We also found positive relationships between blood brominated THM concentrations (sum of BDCM, DBCM and TBM) and risk of ever asthma and between blood DBCM and brominated THM concentrations and risk of current asthma among adolescents with tobacco smoke exposure. The relative excess risk of ever asthma due to the interaction between high blood DBCM and brominated THM concentrations and tobacco smoke exposure was 1.87 (95% CI 0.30-3.43) and 0.78 (95% CI 0.07-1.49), respectively.
conclusionsExposure to THMs is associated with a higher risk of asthma in adolescents, particularly among those exposed to tobacco smoke.
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