Evidence map›Paper›PMID 34625100›Full record

ArticleJournal of medical case reports2021

Cesarean scar pregnancy treatment: a case series.

Zahra Heidar, Shahrzad Zadeh Modarres, Zhila Abediasl, Arezo Khaghani, Ensieh Salehi, Tayebeh Esfidani

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of medical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Advances in Treating Cesarean Scar Pregnancy: A Comprehensive Review of Techniques, Clinical Outcomes, and Fertility Preservation.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Pooled it
  2. Article
  3. Ectopic Pregnancy within a Cesarean Section Scar: An Unusual Case Report.International medical case reports journal · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zahra HeidarClinical Research Development Center, Mahdiyeh Educational Hospital, Shahid Beheshti University of Medical Sciences, Shishe Gar Khaneh Alley, Fadaian Islam Ave, Shoosh Sq, Tehran, Iran.
Shahrzad Zadeh ModarresClinical Research Development Center, Mahdiyeh Educational Hospital, Shahid Beheshti University of Medical Sciences, Shishe Gar Khaneh Alley, Fadaian Islam Ave, Shoosh Sq, Tehran, Iran.
Zhila AbediaslClinical Research Development Center, Mahdiyeh Educational Hospital, Shahid Beheshti University of Medical Sciences, Shishe Gar Khaneh Alley, Fadaian Islam Ave, Shoosh Sq, Tehran, Iran.
Arezo KhaghaniClinical Research Development Center, Mahdiyeh Educational Hospital, Shahid Beheshti University of Medical Sciences, Shishe Gar Khaneh Alley, Fadaian Islam Ave, Shoosh Sq, Tehran, Iran.
Ensieh SalehiFertility and Infertility Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Tayebeh EsfidaniClinical Research Development Center, Mahdiyeh Educational Hospital, Shahid Beheshti University of Medical Sciences, Shishe Gar Khaneh Alley, Fadaian Islam Ave, Shoosh Sq, Tehran, Iran. esfidani.tayebeh@gmail.com.
Shahid Beheshti University of Medical Sciences · IRHormozgan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCesarean scar pregnancy is a complicated and potentially life-threatening type of ectopic pregnancy. This study reports two women with cesarean scar pregnancy who were successfully treated with systemic methotrexate administration, and two other women who needed local re-administration of methotrexate after systemic injection. CASE PRESENTATION: Four Iranian pregnant women aged 29-34 years who were between 5  to 7 gestational weeks with cesarean scar pregnancy diagnosis are described. After a single dose of systemic methotrexate injection, the level of serum beta-human chorionic gonadotropin decreased in two of the women, while fetal activity was observed in the other two women. In the latter patients, methotrexate was injected under transvaginal ultrasound guidance into the gestational sac. As a result, the serum beta-human chorionic gonadotropin level first increased and then decreased in these patients. During the follow-up period, all the patients were stable and no complications were observed. Serum beta-human chorionic gonadotropin levels reached the non-pregnancy range from 4 to 9 weeks after treatment.

conclusionWhen diagnosed at early gestation, cesarean scar pregnancy can be treated successfully with methotrexate administration alone. The clinicians should be aware that the beta-human chorionic gonadotropin level may initially increase after methotrexate injection in some patients. However, the final outcome will be promising if the patients remain stable.

Indexed as

Abortifacient Agents, NonsteroidalPregnancy, EctopicCesarean SectionCicatrixFemaleHumansIranPregnancyAbortifacient Agents, NonsteroidalCase seriesCesarean scar pregnancyMethotrexate

Identifiers

PMID34625100
PMCPMC8501523
OpenAlexW3204176512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.