ArticleBMC women's health2021
Significance of the viral load of high-risk HPV in the diagnosis and prediction of cervical lesions: a retrospective study.
Article in BMC women's health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Risk Factors for Human Papillomavirus Positivity in a Tertiary Care Center: A Case-Control Study Incorporating Genotype Distribution, Co-Infection Patterns, and Quantitative Viral Load Analysis.Journal of clinical medicine · 2026Article
- Correlation between viral load and cervical squamous lesion severity in single and multiple infections: a large-scale analysis.Infectious agents and cancer · 2026Article
- Development of an HPV 16 rapid test founded in user-centered design with primary care clinicians.Analytical methods : advancing methods and applications · 2026Article
- Pathological changes of high-risk human papillomavirus-positive cervical lesions after surgery and analysis of risk factors for persistent positivity.American journal of translational research · 2026Article
- Association between HPV-16 and HPV-18 viral loads and severity of cervical pre-invasive lesions in women with and without HIV in Botswana.Frontiers in oncology · 2026Article
- Integrative molecular diagnostics for HPV-driven cervical carcinogenesis: a translational review of mechanisms and multimodal risk stratification.Frontiers in oncology · 2026Review
- Integrating Biomarkers into Cervical Cancer Screening-Advances in Diagnosis and Risk Prediction: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Human Papillomavirus Viral Load as Triage Biomarker for High-Grade Cervical Lesions and Invasive Cervical Carcinoma: A Cross-Sectional Study.Health science reports · 2025Article
- Performance of thermoablation among women treated for high-risk human papillomavirus in a screen-and-treat program in South Africa.International journal of cancer · 2025Article
- Human Papillomavirus Genotyping and Viral Load as a Predictor of Cervical Lesions: A Prospective Study.Journal of medical virology · 2025Article
- Analysis of HPV-16 viral load, integration status, and p16 expression in relation to EBV co-infection and cervical lesion severity.Scientific reports · 2025Article
- Comparative evaluation of Allplex HPV28 and Anyplex II HPV28 assays for high-risk HPV genotyping in cervical samples.PloS one · 2025Article
- Prevalence of high-risk human papillomavirus genotypes and viral load correlated with squamous cell inflammation among women in Gabon.BMC women's health · 2024Article
- Impact of Excision Type, Cone Volume, and Dimensions on Persistence/Recurrence of Cervical Intraepithelial Neoplasia 2-3.Life (Basel, Switzerland) · 2024Article
- Nonlinear relationship between viral load and TCT in single/multiple HPV52 infection.Virology journal · 2024Article
- The Hallmarks of Cervical Cancer: Molecular Mechanisms Induced by Human Papillomavirus.Biology · 2024Review
- Impact of Red Sea Bream Iridovirus Infection on Rock Bream (Animals : an open access journal from MDPI · 2023Article
- Correlation between human papillomavirus viral load and cervical lesions classification: A review of current research.Frontiers in medicine · 2023Review
- The Effect of Cervical Cold-Knife Conization (CKC) on HPV Infection in Patients with High-Grade Cervical Intraepithelial Neoplasia: A Retrospective Study.International journal of women's health · 2023Article
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Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe significance of HPV viral load in the detection of cervical lesions is still controversial. This study analyzed the correlation between the high-risk HPV viral load and different cervical lesion degrees.
methodsThis retrospective study included women positive for high-risk HPV DNA and screened for cervical lesions between 01/2015 and 06/2018. The high-risk HPV DNA load was measured by the second-generation Hybrid Capture technology and classified as low, moderate, and high. Colposcopy and biopsy were performed in all patients. The patients were grouped as normal, cervical intraepithelial neoplasia (CIN) grade 1, CIN grade 2, CIN grade 3, and cervical cancer. Multivariable logistic regression was performed to explore the association between high-risk HPV DNA load and cervical lesions. The odds ratios (ORs) represent the odds for increasing from low to high viral load.
resultsFinally, 265 patients were grouped as normal (n = 125), CIN 1 (n = 51), CIN 2 (n = 23), CIN 3 (n = 46), and cervical cancer (n = 20). Among them, 139 (52.5%) had a low viral load, 90 (34.0) had a moderate viral load, and 36 (13.4%) had a high viral load. Taking the normal control group as a reference, a high viral load was an independent factor for CIN 1 (OR = 3.568, 95% CI: 1.164-10.941, P = 0.026), CIN 2 (OR = 6.939, 95% CI: 1.793-26.852, P = 0.005), CIN 3 (OR = 7.052, 95% CI: 2.304-21.586, P = 0.001), and cervical cancer (OR = 8.266, 95% CI: 2.120-32.233, P = 0.002).
conclusionsAmong women who underwent cervical biopsy, higher high-risk HPV viral load in cervical lesions was associated with a higher risk of high-grade cervical lesions.
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