Evidence map›Paper›PMID 34625057›Full record

Trial reportBMC musculoskeletal disorders2021

Enhanced recovery after surgery protocols in total knee arthroplasty via midvastus approach: a randomized controlled trial.

Bo Wei, Cheng Tang, Xuxiang Li, Rongcai Lin, Liu Han, Suyang Zheng, Yan Xu, Qingqiang Yao, Liming Wang

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04873544 nacompletednot on this map

Enhanced Recovery After Surgery Protocols in Total Knee Arthroplasty Via Midvastus Approach

TypeinterventionalSponsorNanjing First Hospital, Nanjing Medical UniversityRan2018 to 2020Enrolled69ConditionsERAS, Knee OsteoarthritisArmsERAS protocols for TKA
NCT07655921 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effectiveness of Enhanced Recovery After Surgery (ERAS) Protocols in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Tria

TypeinterventionalSponsorLiaquat National Hospital & Medical CollegeRan2025 to 2026Enrolled120ConditionsERAS, TKAArmsERAS PROTOCOL
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Impact of total hip arthroplasty on low back pain; a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Orthopaedic, trauma surgery, and Covid-2019 pandemic: clinical panorama and future prospective in Europe.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022
    Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bo WeiDepartment of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China.
Cheng TangDepartment of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China.
Xuxiang LiDepartment of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China.
Rongcai LinDepartment of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China.
Liu HanDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China.
Suyang ZhengDepartment of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China.
Yan XuDepartment of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China.
Qingqiang YaoDepartment of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China.
Liming WangDepartment of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China. limingwang99@hotmail.com.ORCID http://orcid.org/0000-0002-1012-3050

Funding

National Natural Science Foundation of China 81702148National Natural Science Foundation of China 81702205National Natural Science Foundation of China 81972042Natural Science Foundation of Jiangsu Province BK20170139
6 · The paper itself

Abstract

backgroundEnhanced recovery after surgery (ERAS) protocols were rapidly adopted in many surgeries such as fast-track arthroplasty. The study aimed to investigate the impact of ERAS protocols on the clinical effect of total knee arthroplasty (TKA) via the midvastus approach.

methodsA total of 69 patients who underwent primary unilateral TKA via the midvastus approach from October 2018 to June 2019 were enrolled and randomly divided into two groups: ERAS group and Control group. The ERAS protocols were adopted for the ERAS group and consisted of pure juice drinking 2 h before the surgery, optimization of the preoperative anesthesia plan, phased use of tourniquets, and the use of tranexamic acid as well as a drug cocktail. The operative time, first postoperative walking time, first straight leg elevation time, postoperative hospitalization time, visual analogue scale score (VAS score), Hospital for Special Surgery score (HSS score), conventional Knee Society score (KSS), and knee range of motion (ROM) were used to assess the clinical effects in the two groups. All the included patients were followed up for 12 months.

resultsThere were no significant differences in the basic demographic information and operation time between the ERAS and Control groups (P > 0.05). The first postoperative walking time (2.11 ± 0.11 h) and first postoperative straight leg elevation time (6.14 ± 1.73 h) in the ERAS group were significantly earlier than those in the Control group (P < 0.001) and the postoperative hospitalization time was significantly shorter (3.11 ± 0.32 days). The postoperative mean VAS scores in both groups were significantly reduced compared with those before surgery (P < 0.001). The VAS scores for the ERAS group were significantly lower than those for the Control group at 1, 2, and 7 days after surgery (P < 0.001). The mean HSS scores, KSS, and knee ROM were significantly increased in both the ERAS and Control groups at 1, 3, 6, and 12 months after surgery (P < 0.001). In addition, the HSS scores, KSS, and knee ROM in the ERAS group were significantly higher than those in the Control group at 1 month after surgery (P < 0.001).

conclusionsERAS protocols improved the clinical effects of TKA via the midvastus approach, facilitating early out-of-bed activity and comfortable postoperative rehabilitation exercise, and further increasing patient satisfaction.

trial registrationClinicalTrials.gov Identifier: NCT04873544 .

Indexed as

Arthroplasty, Replacement, KneeEnhanced Recovery After SurgeryHumansKnee JointRange of Motion, ArticularTourniquetsERASMidvastusOptimization managementTKA

Identifiers

PMID34625057
PMCPMC8501665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.