Evidence map›Paper›PMID 34624637›Full record

ArticleNeuroImage. Clinical2021

Glucose hypometabolism in the Auditory Pathway in Age Related Hearing Loss in the ADNI cohort.

Fatin N Zainul Abidin, Marzia A Scelsi, Sally J Dawson, Andre Altmann, Alzheimer's Disease Neuroimaging Initiative

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Fatin N Zainul AbidinUCL Ear Institute, University College London, London, UK; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Marzia A ScelsiCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Sally J DawsonUCL Ear Institute, University College London, London, UK.
Andre AltmannCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK. Electronic address: a.altmann@ucl.ac.uk.
Alzheimer's Disease Neuroimaging Initiative
University College London · GB

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
CIHRMedical Research Council MR/L016311/1NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

purposeHearing loss (HL) is one of the most common age-related diseases. Here, we investigate the central auditory correlates of HL in people with normal cognition and mild cognitive impairment (MCI) and test their association with genetic markers with the aim of revealing pathogenic mechanisms.

methodsBrain glucose metabolism based on FDG-PET, self-reported HL status, and genetic data were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. FDG-PET data was analysed from 742 control subjects (non-HL with normal cognition or MCI) and 162 cases (HL with normal cognition or MCI) with age ranges of 72.2 ± 7.1 and 77.4 ± 6.4, respectively. Voxel-wise statistics of FDG uptake differences between cases and controls were computed using the generalised linear model in SPM12. An additional 1515 FDG-PET scans of 618 participants were analysed using linear mixed effect models to assess longitudinal HL effects. Furthermore, a quantitative trait genome-wide association study (GWAS) was conducted on the glucose uptake within regions of interest (ROIs), which were defined by the voxel-wise comparison, using genotyping data with 5,082,878 variants available for HL cases and HL controls (N = 817).

resultsThe HL group exhibited hypometabolism in the bilateral Heschl's gyrus (k

conclusionCompared to the non-HL group, glucose metabolism in the HL group was lower in the auditory cortex, the inferior colliculus, and the cochlear nucleus although the effect sizes were small. The GWAS identified candidate genes that might influence FDG uptake in these regions. However, the specific biological pathway(s) underlying the role of these genes in FDG-hypometabolism in the auditory pathway requires further investigation.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAuditory PathwaysBrainFluorodeoxyglucose F18Genome-Wide Association StudyGlucoseHumansNeuroimagingPositron-Emission TomographyFluorodeoxyglucose F18Glucose18F-FDG PETADNIGenome-wide association study Auditory cortexHearing lossHeschl’s gyrusInferior colliculusNeuroimaging geneticsVolume of interest analysis

Identifiers

PMID34624637
PMCPMC8503577
OpenAlexW3199623556

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.