ArticleJournal of psychiatric research2021
Cognitive function mediates the relationship between visual contrast sensitivity and functional outcome in schizophrenia.
Article in Journal of psychiatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Stereopsis deficits in schizophrenia: a systematic review with exploratory meta-analysis.BMC psychiatry · 2026Pooled it
- Visual remediation of contrast processing impairments in schizophrenia: A preliminary clinical trial.Schizophrenia research · 2024Trial
- Perceptual organization and its relationship to functioning in patients with chronic schizophrenia.Schizophrenia research. Cognition · 2026Article
- Visual suppression deficits as a biomarker of working memory impairment in schizophrenia.Schizophrenia research. Cognition · 2026Review
- Contrast sensitivity and subjective visual disturbances across the psychosis continuum.Cognitive neuropsychiatry · 2026Article
- Systematic review and meta-analysis of early visual processing, social cognition, and functional outcomes in schizophrenia spectrum disorders.Schizophrenia research. Cognition · 2025Review
- The Relationship between Clinical and Psychophysical Assessments of Visual Perceptual Disturbances in Individuals at Clinical High Risk for Psychosis: A Preliminary Study.Brain sciences · 2024Article
- Frequency-domain analysis of transient visual evoked potentials in schizophrenia.Documenta ophthalmologica. Advances in ophthalmology · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundIndividuals with schizophrenia exhibit deficits in visual contrast processing, though less is known about how these deficits impact neurocognition and functional outcomes. This study investigated effects of contrast sensitivity (CS) on cognition and capacity for independent living in schizophrenia.
methodsParticipants were 58 patients with schizophrenia (n = 49) and schizoaffective disorder (n = 9). Patients completed a psychophysical paradigm to obtain CS with stimuli consisting of grating patterns of low (0.5 and 1 cycles/degree) and high spatial frequencies (4, 7, 21 cycles/degree). Patients completed the MATRICS Consensus Cognitive Battery and Wechsler Adult Intelligence Scales, Third Edition to assess cognition, and the problem-solving factor of the Independent Living Scales to assess functional capacity. We computed bivariate correlation coefficients for all pairs of variables and tested mediation models with CS to low (CS-LSF) and high spatial frequencies (CS-HSF) as predictors, cognitive measures as mediators, and capacity for independent living as an outcome.
resultsCognition mediated the relationship between CS and independent living with CS-LSF a stronger predictor than CS-HSF. Mediation effects were strongest for perceptual organization and memory-related domains. In an expanded moderated mediation model, CS-HSF was found to be a significant predictor of independent living through perceptual organization as a mediator and CS-LSF as a moderator of this relationship.
conclusionCS relates to functional capacity in schizophrenia through neurocognition. These relationships may inform novel visual remediation interventions.
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