Evidence map›Paper›PMID 34624542›Full record

ReviewInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2021

Role of multiple factors likely contributing to severity-mortality of COVID-19.

Jasdeep Singh, Anwar Alam, Jasmine Samal, Markus Maeurer, Nasreen Z Ehtesham, Jeremiah Chakaya, Subhash Hira, Seyed E Hasnain

Abstract readReview
In one paragraph

Review in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. COVID-19 and tuberculosis: the double whammy of respiratory pathogens.European respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jasdeep SinghDepartment of Biochemical Engineering and Biotechnology, Indian Institute of Technology-Delhi, New Delhi, India.
Anwar AlamICMR National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India.
Jasmine SamalICMR National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India.
Markus MaeurerImmunoSurgery Unit, Champalimaud Centre for the Unknown, Lisbon, Portugal; Medizinische Klinik, Johannes Gutenberg University Mainz, Germany; Division of Infection and Immunity, University College London, London, UK; NIHR Biomedical Research Centre, University College London Hospitals, London, UK.
Nasreen Z EhteshamICMR National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India.
Jeremiah ChakayaDivision of Infection and Immunity, University College London, London, UK; NIHR Biomedical Research Centre, University College London Hospitals, London, UK; Department of Medicine, Therapeutics, Dermatology and Psychiatry, Kenyatta University, Nairobi, Kenya. Electronic address: chakaya.jm@gmail.com.
Subhash HiraDepartment of Global Health, University of Washington-Seattle, USA. Electronic address: Hiras2@uw.edu.
Seyed E HasnainDepartment of Biochemical Engineering and Biotechnology, Indian Institute of Technology-Delhi, New Delhi, India; Department of Life Science, School of Basic Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India. Electronic address: seyed.hasnain@sharda.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 stalled the world in 2020 and continues to be the greatest health crisis of this generation. While the apparent case fatality rates across fluctuates around ~2% globally, associated mortality/death rate (deaths per million population) varies distinctly across regions from the global average of ~600 per million population. Heterogeneous factors have been linked with COVID-19 associated mortalities and these include age, share of geriatric population, comorbidities, trained immunity and climatic conditions. Apart from direct or indirect role of endemic diseases, dietary factors and host immunity in regulating COVID-19 severity, human behaviour will inevitably control outcome of this pandemic. Comprehensive understanding of these factors will have a bearing on management of future health crises.

Indexed as

Angiotensin-Converting Enzyme 2ComorbidityCOVID-19Diabetes MellitusDietHumansImmunity, InnatePolymorphism, GeneticVaccinesACE2 protein, humanAngiotensin-Converting Enzyme 2VaccinesACE2COVID-19DiabetesHuman behaviourImmuno-nutritionSARS-CoV-2Trained immunity

Identifiers

PMID34624542
PMCPMC8491954

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.