ReviewNeuroscience and biobehavioral reviews2021
Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework.
Review in Neuroscience and biobehavioral reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Remote Mindfulness Training for Health Following Early Life Adversity: A Randomized Controlled Feasibility Trial.Behavior therapy · 2026Article
- Early life adversity and adult attention-deficit/hyperactivity disorder (ADHD): Pathways to persistence and adult susceptibility.Neuroscience and biobehavioral reviews · 2025Review
- The moderating effect of lifetime physical activity on brain alterations related to adverse childhood experiences.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Associations between U.S. County-Level Social Infrastructure and Dementia among Medicare Beneficiaries, 2020.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
- Exploring the correlation between childhood trauma experiences, inflammation, and brain activity in first-episode, drug-naive major depressive disorder.European archives of psychiatry and clinical neuroscience · 2025Article
- Physical Activities and Parkinson's Disease Progression: A Two-Sample Mendelian Randomization Study.CNS neuroscience & therapeutics · 2025Article
- Sex Differences in the Associations Among Early Life Adversity, Inflammation, and Cognition.Biomolecules · 2025Review
- The psychological costs of behavioral immunity following COVID-19 diagnosis.Scientific reports · 2024Article
- The impact of early adversity on the cerebral cortex - a Mendelian randomization study.Frontiers in neuroscience · 2023Article
- Physical activities and risk of neurodegenerative diseases: A two-sample Mendelian randomization study.Frontiers in aging neuroscience · 2022Article
- Adult Health and Early Life Adversity: Behind the Curtains of Maternal Care Research.Frontiers in physiology · 2022Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Adverse childhood experiences such as abuse, neglect, and poverty, profoundly alter neurobehavioral development in a manner that negatively impacts health across the lifespan. Adults who have been exposed to such adversities exhibit premature and more severe age-related declines in brain health. Unfortunately, it remains unclear whether the negative effects of early life adversity (ELA) on brain health can be remediated through intervention in adulthood. Physical activity may represent a low-cost behavioral approach to address the long-term consequences of ELA on brain health. However, there has been limited research examining the impact of physical activity on brain health among adults with a history of ELA. Accordingly, the purpose of this review is to (1) review the influence of ELA on brain health in adulthood and (2) highlight evidence for the role of neurotrophic factors, hypothalamic-adrenal-pituitary axis regulation, inflammatory processes, and epigenetic modifications in mediating the effects of both ELA and physical activity on brain health outcomes in adulthood. We then propose a theoretical framework to guide future research in this area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.