ArticleToxicology and applied pharmacology2021
Subclinical markers of cardiovascular toxicity of benzene inhalation in mice.
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Article in Toxicology and applied pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Advances in biomarkers of benzene exposure and toxicity: From mechanistic insights to occupational health applications (Review).Molecular medicine reports · 2026Review
- Gaseous Air Pollutant Exposure and Atherosclerosis: A Systematic Study Integrating Multi-Omics and Network Toxicology.International journal of molecular sciences · 2026Article
- Exploring the Impact of E‑Waste Exposure on Childhood Blood Pressure: Metabolomics Analysis and Risk Prediction.Environment & health (Washington, D.C.) · 2026Article
- A Population-Centered Health Framework for Analyzing Superfund Sites With a History of Volatile Organic Compound Contamination.Community health equity research & policy · 2026Article
- Long-term exposure to low concentrations of ambient benzene with incident thyroid dysfunction and the mediating role of accelerated biological aging.Frontiers in public health · 2026Article
- Article
- Benzene metabolites increase vascular permeability by activating heat shock proteins and Rho GTPases.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- A workflow for human health hazard evaluation using transcriptomic data and Key Characteristics-based gene sets.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Chronic benzene exposure impairs the self-renewal capacity of HSPCs in C57BL/6 mice.Toxicology research · 2025Article
- Association of the blood levels of specific volatile organic compounds with nonfatal cardio-cerebrovascular events in US adults.BMC public health · 2024Observational
- The impact of environmental contaminants on extracellular vesicles and their key molecular regulators: A literature and database-driven review.Environmental and molecular mutagenesis · 2023Review
- Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery Areas.Toxics · 2022Review
- Tobacco product use and the risks of SARS-CoV-2 infection and COVID-19: current understanding and recommendations for future research.The Lancet. Respiratory medicine · 2022Review
- Environmental Exposures and Extracellular Vesicles: Indicators of Systemic Effects and Human Disease.Current environmental health reports · 2022Review
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Marina V MalovichkoUniversity of Louisville Superfund Research Center, University of Louisville, Louisville, KY 40202, United States of America; American Heart Association-Tobacco Center of Regulatory Science, University of Louisville, Louisville, KY 40202, United States of America; Envirome Institute, University of Louisville, Louisville, KY 40202, United States of America; Department of Medicine, Division of Environmental Medicine, University of Louisville, Louisville, KY 40202, United States of America.
Wesley T AbplanalpUniversity of Louisville Superfund Research Center, University of Louisville, Louisville, KY 40202, United States of America; Department of Medicine, Division of Environmental Medicine, University of Louisville, Louisville, KY 40202, United States of America.
Samantha A McFallUniversity of Louisville Superfund Research Center, University of Louisville, Louisville, KY 40202, United States of America; Envirome Institute, University of Louisville, Louisville, KY 40202, United States of America; Department of Medicine, Division of Environmental Medicine, University of Louisville, Louisville, KY 40202, United States of America.
Breandon S TaylorUniversity of Louisville Superfund Research Center, University of Louisville, Louisville, KY 40202, United States of America; Envirome Institute, University of Louisville, Louisville, KY 40202, United States of America; Department of Medicine, Division of Environmental Medicine, University of Louisville, Louisville, KY 40202, United States of America.
Nalinie S WickramasingheUniversity of Louisville Superfund Research Center, University of Louisville, Louisville, KY 40202, United States of America; American Heart Association-Tobacco Center of Regulatory Science, University of Louisville, Louisville, KY 40202, United States of America; Envirome Institute, University of Louisville, Louisville, KY 40202, United States of America; Department of Medicine, Division of Environmental Medicine, University of Louisville, Louisville, KY 40202, United States of America.
Israel D SithuUniversity of Louisville Superfund Research Center, University of Louisville, Louisville, KY 40202, United States of America; American Heart Association-Tobacco Center of Regulatory Science, University of Louisville, Louisville, KY 40202, United States of America; Envirome Institute, University of Louisville, Louisville, KY 40202, United States of America; Department of Medicine, Division of Environmental Medicine, University of Louisville, Louisville, KY 40202, United States of America.
Igor N ZelkoUniversity of Louisville Superfund Research Center, University of Louisville, Louisville, KY 40202, United States of America; American Heart Association-Tobacco Center of Regulatory Science, University of Louisville, Louisville, KY 40202, United States of America; Envirome Institute, University of Louisville, Louisville, KY 40202, United States of America; Department of Medicine, Division of Environmental Medicine, University of Louisville, Louisville, KY 40202, United States of America.
Shizuka UchidaUniversity of Louisville Superfund Research Center, University of Louisville, Louisville, KY 40202, United States of America; Envirome Institute, University of Louisville, Louisville, KY 40202, United States of America; Department of Medicine, Division of Environmental Medicine, University of Louisville, Louisville, KY 40202, United States of America.
Bradford G HillUniversity of Louisville Superfund Research Center, University of Louisville, Louisville, KY 40202, United States of America; Envirome Institute, University of Louisville, Louisville, KY 40202, United States of America; Department of Medicine, Division of Environmental Medicine, University of Louisville, Louisville, KY 40202, United States of America.
Saurin R SutariaUniversity of Louisville Superfund Research Center, University of Louisville, Louisville, KY 40202, United States of America; Department of Chemistry, University of Louisville, Louisville, KY 40202, United States of America.
Michael H NantzUniversity of Louisville Superfund Research Center, University of Louisville, Louisville, KY 40202, United States of America; Department of Chemistry, University of Louisville, Louisville, KY 40202, United States of America.
Aruni BhatnagarUniversity of Louisville Superfund Research Center, University of Louisville, Louisville, KY 40202, United States of America; American Heart Association-Tobacco Center of Regulatory Science, University of Louisville, Louisville, KY 40202, United States of America; Envirome Institute, University of Louisville, Louisville, KY 40202, United States of America; Department of Medicine, Division of Environmental Medicine, University of Louisville, Louisville, KY 40202, United States of America.
Daniel J ConklinUniversity of Louisville Superfund Research Center, University of Louisville, Louisville, KY 40202, United States of America; American Heart Association-Tobacco Center of Regulatory Science, University of Louisville, Louisville, KY 40202, United States of America; Envirome Institute, University of Louisville, Louisville, KY 40202, United States of America; Department of Medicine, Division of Environmental Medicine, University of Louisville, Louisville, KY 40202, United States of America.
Timothy E O'TooleUniversity of Louisville Superfund Research Center, University of Louisville, Louisville, KY 40202, United States of America; American Heart Association-Tobacco Center of Regulatory Science, University of Louisville, Louisville, KY 40202, United States of America; Envirome Institute, University of Louisville, Louisville, KY 40202, United States of America; Department of Medicine, Division of Environmental Medicine, University of Louisville, Louisville, KY 40202, United States of America.
Sanjay SrivastavaUniversity of Louisville Superfund Research Center, University of Louisville, Louisville, KY 40202, United States of America; American Heart Association-Tobacco Center of Regulatory Science, University of Louisville, Louisville, KY 40202, United States of America; Envirome Institute, University of Louisville, Louisville, KY 40202, United States of America; Department of Medicine, Division of Environmental Medicine, University of Louisville, Louisville, KY 40202, United States of America. Electronic address: sanjay@louisville.edu.
University of Louisville · USAmerican Heart Association · US
Funding
ConProject-006U54HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2018 to 2022
$18.8MSuperfund Training CoreP42ES023716 · NIEHS · UNIVERSITY OF LOUISVILLE · PI SRIVASTAVA, SANJAY · 2017 to 2025
$18.1MUniversity of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0MUrban Greenness and Cardiovascular HealthR01ES029846 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Aruni Bhatnagar · 2018 to 2026
$6.2MCardiovascular Toxicity of Tobacco Products and ConstituentsR01HL122676 · NHLBI · UNIVERSITY OF LOUISVILLE · PI CONKLIN, DANIEL JOSEPH · 2015 to 2019
$3.7MMolecular Regulation of AtherosclerosisR01HL146134 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, SRIVASTAVA, SANJAY · 2019 to 2022
$3.3MThe role of signaling adaptor protein epsin in atherosclerosisR01HL156362 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, SHI, JINJUN · 2021 to 2024
$3.1MAtherogenic Mechanisms of Electronic Nicotine Delivery SystemsR01HL149351 · NHLBI · UNIVERSITY OF LOUISVILLE · PI SRIVASTAVA, SANJAY · 2020 to 2023
$2.9MMolecular Mechanisms Regulating Endothelial DysfunctionR01HL137229 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, SRIVASTAVA, SANJAY · 2017 to 2020
$2.7MUSING FORTILIN INHIBITORS TO BLOCK ATHEROSCLEROSISR01HL138992 · NHLBI · UNIVERSITY OF WASHINGTON · PI FUJISE, KEN, SRIVASTAVA, SANJAY · 2017 to 2020
$2.6MCardiovascular Benefits of Inhaled Biogenic Volatile Organic CompoundsR21ES033323 · NIEHS · UNIVERSITY OF LOUISVILLE · PI CONKLIN, DANIEL JOSEPH · 2021 to 2022
$430kNHLBI NIH HHS R01 HL122676NHLBI NIH HHS R01 HL137229NHLBI NIH HHS R01 HL138992NHLBI NIH HHS R01 HL146134NHLBI NIH HHS R01 HL149351NHLBI NIH HHS R01 HL156362NHLBI NIH HHS U54 HL120163NIEHS NIH HHS P30 ES030283NIEHS NIH HHS P42 ES023716NIEHS NIH HHS R01 ES029846NIEHS NIH HHS R21 ES033323
Abstract
Benzene is a ubiquitous environmental pollutant. Recent population-based studies suggest that benzene exposure is associated with an increased risk for cardiovascular disease. However, it is unclear whether benzene exposure by itself is sufficient to induce cardiovascular toxicity. We examined the effects of benzene inhalation (50 ppm, 6 h/day, 5 days/week, 6 weeks) or HEPA-filtered air exposure on the biomarkers of cardiovascular toxicity in male C57BL/6J mice. Benzene inhalation significantly increased the biomarkers of endothelial activation and injury including endothelial microparticles, activated endothelial microparticles, endothelial progenitor cell microparticles, lung endothelial microparticles, and activated lung and endothelial microparticles while having no effect on circulating levels of endothelial adhesion molecules, endothelial selectins, and biomarkers of angiogenesis. To understand how benzene may induce endothelial injury, we exposed human aortic endothelial cells to benzene metabolites. Of the metabolites tested, trans,trans-mucondialdehyde (10 μM, 18h) was the most toxic. It induced caspases-3, -7 and -9 (intrinsic pathway) activation and enhanced microparticle formation by 2.4-fold. Levels of platelet-leukocyte aggregates, platelet macroparticles, and a proportion of CD4
Indexed as
AnimalsAsymptomatic DiseasesBenzeneBiomarkersBlood PlateletsCardiotoxicityCardiovascular DiseasesCardiovascular SystemCell-Derived MicroparticlesEndothelial CellsHematopoietic Stem CellsInhalation ExposureLeukocytesMaleMiceMice, Inbred C57BLBenzeneBiomarkersBenzeneEndothelial cellsInflammationMicroparticlesPlatelets
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