Evidence map›Paper›PMID 34624335›Full record

ArticleExperimental eye research2021

β-Cleavage of the prion protein in the human eye: Implications for the spread of infectious prions and human ocular disorders.

Suman Chaudhary, Ajay Ashok, Aaron S Wise, Neil A Rana, Alexander E Kritikos, Ewald Lindner, Neena Singh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Suman ChaudharyDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Ajay AshokDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Aaron S WiseDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Neil A RanaDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Alexander E KritikosDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Ewald LindnerDepartment of Ophthalmology, Medical University of Graz, Auenbruggerplatz 4, 8036, Graz, Austria.
Neena SinghDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA. Electronic address: neena.singh@case.edu.
Case Western Reserve University · USMedical University of Graz · AT

Funding

The iron modulatory function of prion protein and prion disordersR01NS092145 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI SINGH, NEENA · 2015 to 2019
$2.4M
Local hepcidin in the anterior segment: Physiological and pathological implicationsR21EY032694 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI SINGH, NEENA · 2022 to 2023
$443k
Modulation of brain iron by local hepcidin in prion disordersR21NS125228 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI SINGH, NEENA · 2021 to 2021
$443k
NEI NIH HHS R21 EY032694NINDS NIH HHS R01 NS092145NINDS NIH HHS R21 NS125228
6 · The paper itself

Abstract

Recently, we reported β-cleavage of the prion protein (PrP

Indexed as

AnimalsCell LineDisease Models, AnimalEye DiseasesHumansMicePrPC ProteinsRetinal Pigment EpitheliumRNA CleavagePrPC ProteinsAqueous humorPrion proteinRetinaVitreous humorβ-Cleavage

Identifiers

PMID34624335
PMCPMC8608713
OpenAlexW3204127007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.