Evidence map›Paper›PMID 34624328›Full record

Trial reportExperimental neurology2022

Acute intermittent hypoxia and respiratory muscle recruitment in people with amyotrophic lateral sclerosis: A preliminary study.

Elaheh Sajjadi, Yasin B Seven, Jessica G Ehrbar, James P Wymer, Gordon S Mitchell, Barbara K Smith

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Experimental neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05377424 (Acute Adenosine Receptor Antagonism to Promote Breathing Plasticity in ALS), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05377424 phase1 / phase2active not recruitingnot on this map

Acute Adenosine Receptor Antagonism to Promote Breathing Plasticity in ALS

TypeinterventionalSponsorUniversity of FloridaRan2022 to 2026Enrolled40ConditionsALSArmsConsume 20mg of istradefylline, Low Oxygen therapy, Placebo counterpart to the istradefylline drug, SHAM counterpart to low oxygen therapy.
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Phrenic long-term facilitation following acute intermittent hypercapnic-hypoxia in rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elaheh SajjadiBreathing Research and Therapeutics Center, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA; Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA.
Yasin B SevenBreathing Research and Therapeutics Center, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA; Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA.
Jessica G EhrbarDepartment of Physical Therapy, University of Florida, Gainesville, FL 32610, USA.
James P WymerBreathing Research and Therapeutics Center, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA; Neurology, University of Florida, Gainesville, FL 32610, USA.
Gordon S MitchellBreathing Research and Therapeutics Center, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA; Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA.
Barbara K SmithBreathing Research and Therapeutics Center, University of Florida, Gainesville, FL 32610, USA; Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA; Pediatrics, University of Florida, Gainesville, FL 32610, USA. Electronic address: bksmith@phhp.ufl.edu.
University of Florida · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
NCATS NIH HHS UL1 TR001427
6 · The paper itself

Abstract

Respiratory failure is the main cause of death in amyotrophic lateral sclerosis (ALS). Since no effective treatments to preserve independent breathing are available, there is a critical need for new therapies to preserve or restore breathing ability. Since acute intermittent hypoxia (AIH) elicits spinal respiratory motor plasticity in rodent ALS models, and may restore breathing ability in people with ALS, we performed a proof-of-principle study to investigate this possibility in ALS patients. Quiet breathing, sniff nasal inspiratory pressure (SNIP) and maximal inspiratory pressure (MIP) were tested in 13 persons with ALS and 10 age-matched controls, before and 60 min post-AIH (15, 1 min episodes of 10% O

Indexed as

HypoxiaAgedAmyotrophic Lateral SclerosisFemaleHumansMaleMiddle AgedRespiratory MechanicsRespiratory MusclesAcute intermittent hypoxiaAIHALSAmyotrophic lateral sclerosisControl of breathingRespiratory muscle activityRespiratory plasticitySurface EMG

Identifiers

PMID34624328
PMCPMC9488543
OpenAlexW3201943836

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.