ArticleNeuron2021
Transcriptional and functional divergence in lateral hypothalamic glutamate neurons projecting to the lateral habenula and ventral tegmental area.
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Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47citing papers in PubMed
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Who cites it
47 citing papers in PubMed.
- Mesohabenular glutamatergic regulation of the consequences of uncontrollable stress.bioRxiv : the preprint server for biology · 2026Article
- Article
- Article
- Novelty exploration-activated ensemble in the lateral hypothalamus confers analgesic and anxiolytic effects.Nature communications · 2026Article
- A prefrontal cortex-lateral hypothalamus circuit controls stress-driven increased food intake.Nature communications · 2026Article
- Increased c-Fos expression in lateral habenula during social transmission of negative valence in prairie voles.Molecular autism · 2026Article
- A novel theory of rapid eye movement sleep as an integral component of the seasonal timekeeping apparatus.Frontiers in neuroscience · 2026Article
- Individual paraventricular hypothalamic GLP-1R neurons track ingestion across energy states.iScience · 2025Article
- Review
- A striosomal accumbens pathway drives stereotyped behavior through an aversive Esr1+ hypothalamic-habenula circuit.Science advances · 2025Article
- Lateral hypothalamus CRFR1 regulation of chronic binge drinking: divergence along anterior-posterior axis.bioRxiv : the preprint server for biology · 2025Article
- The expression profile of type 1 equilibrative nucleoside transporter in aged C57BL/6J mouse brain.Acta biochimica et biophysica Sinica · 2025Article
- Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal.Neuron · 2025Article
- Review
- A hypothalamus-brainstem circuit governs the prioritization of safety over essential needs.Nature neuroscience · 2025Article
- State-dependent central synaptic regulation by GLP-1 is essential for energy homeostasis.Nature metabolism · 2025Article
- Lateral habenula induces cognitive and affective dysfunctions in mice with neuropathic pain via an indirect pathway to the ventral tegmental area.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Energy state guides reward seeking via an extended amygdala to lateral hypothalamus pathway.Nature communications · 2025Article
- Lateral hypothalamus and eating: cell types, molecular identity, anatomy, temporal dynamics and functional roles.Experimental & molecular medicine · 2025Review
- A cell-type-specific circuit of somatostatin neurons in the habenula encodes antidepressant action in male mice.Nature communications · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Mark A RossiCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Marcus L BasiriCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195, USA; Neuroscience Curriculum, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.
Yuejia LiuCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Yoshiko HashikawaCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Koichi HashikawaCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Lief E FennoDepartments of Psychiatry and Behavioral Sciences and Bioengineering, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Yoon Seok KimDepartments of Psychiatry and Behavioral Sciences and Bioengineering, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Charu RamakrishnanDepartments of Psychiatry and Behavioral Sciences and Bioengineering, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Karl DeisserothDepartments of Psychiatry and Behavioral Sciences and Bioengineering, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Garret D StuberCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195, USA. Electronic address: gstuber@uw.edu.
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008719 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DARVILLE, TONI, DESHMUKH, MOHANISH P · 1999 to 2023
$15.1MUniversity of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI LARRY S ZWEIFEL · 2019 to 2026
$13.0MRESEARCH TRAINING IN THE NEUROSCIENCEST32NS007431 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Juan Song, Mark J. Zylka · 1997 to 2026
$10.0MStructural and molecular identification of circuitry underlying joint processing of motivation and aversionR37DA035377 · NIDA · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2013 to 2022
$6.2MNeural circuit elements that orchestrate cue-reward associationsR37DA032750 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Garret D Stuber · 2017 to 2026
$4.5MLateral Hypothalamic Circuits for Feeding and ReinforcementR01DA038168 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STUBER, GARRET D · 2014 to 2025
$4.0MMidbrain Neural Circuit Elements That Underlie Cue-Reward AssociationsR01DA032750 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STUBER, GARRET D · 2012 to 2016
$1.6MDisentangling discrete lateral hypothalamic circuits involved in feeding and obesityR00DK121883 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ROSSI, MARK ALLEN · 2021 to 2023
$735kDisentangling discrete lateral hypothalamic circuits involved in feeding and obesityK99DK121883 · NIDDK · UNIVERSITY OF WASHINGTON · PI ROSSI, MARK ALLEN · 2019 to 2020
$181kNIDA NIH HHS P30 DA048736NIDA NIH HHS R01 DA032750NIDA NIH HHS R01 DA038168NIDA NIH HHS R37 DA032750NIDA NIH HHS R37 DA035377NIDDK NIH HHS K99 DK121883NIDDK NIH HHS R00 DK121883NIGMS NIH HHS T32 GM008719NINDS NIH HHS T32 NS007431
Abstract
The lateral hypothalamic area (LHA) regulates feeding- and reward-related behavior, but because of its molecular and anatomical heterogeneity, the functions of defined neuronal populations are largely unclear. Glutamatergic neurons within the LHA (LHA
Indexed as
HabenulaHypothalamic Area, LateralGlutamic AcidNeural PathwaysNeuronsVentral Tegmental AreaGlutamic Acidcalcium imagingelectrophysiologyghrelinlateral habenulalateral hypothalamic arealeptinsingle-cell sequencingventral tegmental area
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.