ArticleCell reports2021
Role of miR-2392 in driving SARS-CoV-2 infection.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Role of the MicroRNAs in the Pathogenic Mechanism of Painful Symptoms in Long COVID: Systematic Review.International journal of molecular sciences · 2023Pooled it
- Investigating the Role of microRNA in Host-Influenza A and Other Respiratory RNA Virus Interactions.Pathogens (Basel, Switzerland) · 2026Review
- Mitochondrial-Epigenetic Crosstalk in Autism Spectrum Disorder: Linking Cellular Stress to Synaptic Dysfunction and Treatment Resistance.Molecular neurobiology · 2026Review
- The regulatory mechanisms and translational applications of non-coding RNA in SARS-CoV-2 infection-related cardiovascular pathology.Frontiers in cardiovascular medicine · 2026Review
- A Systems Biology Approach to Discovery and Validation of MicroRNA Signature Health Risks Associated with the Space Environment.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Multi-omics analysis of long COVID (post-COVID-19 condition) reveals persistent mitochondrial dysfunction, suppressed oxidative phosphorylation, and immune dysregulation.Frontiers in immunology · 2026Article
- miRNA biomarkers for prognosis and therapy monitoring in a multi-ethnic cohort with SARS-CoV-2 infection.Scientific reports · 2025Article
- Kidney Stone Disease: Epigenetic Dysregulation in Homocystinuria and Mitochondrial Sulfur Trans-Sulfuration Ablation Driven by COVID-19 Pathophysiology.Biomolecules · 2025Review
- MicroRNAs in long COVID: roles, diagnostic biomarker potential and detection.Human genomics · 2025Review
- Telomere Length, Oxidative Stress Markers, and Related miRNAs in Non-Invasive Samples of Mild COVID-19 Cases.International journal of molecular sciences · 2025Article
- Suppression of NF-κB/NLRP3 by nanoligomer therapy mitigates ethanol and advanced age-related neuroinflammation.Journal of leukocyte biology · 2025Article
- The relationship between microRNAs and COVID-19 complications.Non-coding RNA research · 2025Review
- Recent advances in the development and clinical application of miRNAs in infectious diseases.Non-coding RNA research · 2025Review
- Vitamin D and Mitochondrial Activity Preservation in COVID-19.Infectious disorders drug targets · 2025Article
- Plasma miR-1-3p levels predict severity in hospitalized COVID-19 patients.British journal of pharmacology · 2025Article
- The Molecular Basis of Asthma Exacerbations Triggered by Viral Infections: The Role of Specific miRNAs.International journal of molecular sciences · 2024Review
- Diagnosis, Severity, and Prognosis from Potential Biomarkers of COVID-19 in Urine: A Review of Clinical and Omics Results.Metabolites · 2024Review
- Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Large- and Small-Animal Studies of Safety, Pharmacokinetics, and Biodistribution of Inflammasome-Targeting Nanoligomer in the Brain and Other Target Organs.ACS pharmacology & translational science · 2024Article
- sChemNET: a deep learning framework for predicting small molecules targeting microRNA function.Nature communications · 2024Article
Corrections and comments
- Update of
Authors and funding
49 authors at 20 institutions in 5 countries.
J Tyson McDonaldCOVID-19 International Research Team; Georgetown University School of Medicine, Washington, DC 20007, USA.
Francisco J EnguitaCOVID-19 International Research Team; Instituto de Medicina Molecular João Lobo Antunes, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal.
Deanne TaylorCOVID-19 International Research Team; The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; University of Pennsylvania, Philadelphia, PA 19104, USA.
Robert J GriffinCOVID-19 International Research Team; University of Arkansas for Medical Sciences, Little Rock, AK 72211, USA.
Waldemar PriebeCOVID-19 International Research Team; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mark R EmmettCOVID-19 International Research Team; University of Texas Medical Branch, Galveston, TX 77555, USA.
Mohammad M SajadiUniversity of Maryland School of Medicine, Baltimore, MD 21201, USA.
Anthony D HarrisUniversity of Maryland School of Medicine, Baltimore, MD 21201, USA.
Jean ClementUniversity of Maryland School of Medicine, Baltimore, MD 21201, USA.
Joseph M DybasCOVID-19 International Research Team; The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Nukhet Aykin-BurnsUniversity of Pennsylvania, Philadelphia, PA 19104, USA.
Joseph W GuarnieriCOVID-19 International Research Team; The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Larry N SinghCOVID-19 International Research Team; The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Peter GrabhamCOVID-19 International Research Team; Columbia University, New York, NY 10032, USA.
Stephen B BaylinCOVID-19 International Research Team; Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Aliza YouseyCOVID-19 International Research Team; Morehouse School of Medicine, Atlanta, GA 30310, USA.
Andrea N PearsonMorehouse School of Medicine, Atlanta, GA 30310, USA.
Peter M CorryCOVID-19 International Research Team; University of Arkansas for Medical Sciences, Little Rock, AK 72211, USA.
Amanda Saravia-ButlerCOVID-19 International Research Team; Logyx LLC, Mountain View, CA 94043, USA; NASA Ames Research Center, Moffett Field, CA 94035, USA.
Thomas R AuninsUniversity of Colorado Boulder, Boulder, CO 80303, USA.
Sadhana SharmaUniversity of Colorado Boulder, Boulder, CO 80303, USA; Sachi Bioworks Inc., Boulder, CO 80301, USA.
Prashant NagpalSachi Bioworks Inc., Boulder, CO 80301, USA; Antimicrobial Regeneration Consortium, Boulder Labs, Boulder, CO 80301, USA; Quantum Biology Inc., Boulder, CO 80301, USA.
Cem MeydanWeill Cornell Medicine, New York, NY 10065, USA.
Jonathan FooxWeill Cornell Medicine, New York, NY 10065, USA.
Christopher MozsaryWeill Cornell Medicine, New York, NY 10065, USA.
Bianca CerqueiraCOVID-19 International Research Team; KBR Space & Science, San Antonio, TX 78235, USA; United States Air Force School of Aerospace Medicine, Lackland AFB, San Antonio, TX 78236, USA.
Viktorija ZaksasCOVID-19 International Research Team; University of Chicago, Chicago, IL 60615, USA.
Urminder SinghCOVID-19 International Research Team; Iowa State University, Ames, IA 50011, USA.
Eve Syrkin WurteleCOVID-19 International Research Team; Iowa State University, Ames, IA 50011, USA.
Sylvain V CostesNASA Ames Research Center, Moffett Field, CA 94035, USA.
Gustavo Gastão DavanzoUniversity of Campinas, Sao Paulo, Brazil.
Diego GaleanoCOVID-19 International Research Team; Fundação Getulio Vargas, Rio de Janeiro, Brazil; National University of Asuncion, San Lorenzo, Central, Paraguay.
Alberto PaccanaroCOVID-19 International Research Team; Fundação Getulio Vargas, Rio de Janeiro, Brazil; University of London, Egham Hill, Egham, UK.
Suzanne L MeinigUniversity of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Robert S HaganUniversity of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Natalie M BowmanUniversity of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
UNC COVID-19 Pathobiology ConsortiumUniversity of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Matthew C WolfgangUniversity of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Selin AltinokUniversity of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Nicolae SapovalRice University, Houston, TX 77005, USA.
Todd J TreangenRice University, Houston, TX 77005, USA.
Pedro M Moraes-VieiraCOVID-19 International Research Team; University of Campinas, Sao Paulo, Brazil.
Charles VanderburgBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Douglas C WallaceCOVID-19 International Research Team; The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; University of Pennsylvania, Philadelphia, PA 19104, USA.
Jonathan C SchislerCOVID-19 International Research Team; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Christopher E MasonCOVID-19 International Research Team; Weill Cornell Medicine, New York, NY 10065, USA; New York Genome Center, New York, NY, USA.
Anushree ChatterjeeCOVID-19 International Research Team; University of Colorado Boulder, Boulder, CO 80303, USA; Sachi Bioworks Inc., Boulder, CO 80301, USA; Antimicrobial Regeneration Consortium, Boulder Labs, Boulder, CO 80301, USA.
Robert MellerCOVID-19 International Research Team; Morehouse School of Medicine, Atlanta, GA 30310, USA.
Afshin BeheshtiCOVID-19 International Research Team; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; KBR, NASA Ames Research Center, Moffett Field, CA 94035, USA. Electronic address: afshin.beheshti@nasa.gov.
University of North Carolina at Chapel Hill · USChildren's Hospital of Philadelphia · USUniversity of Colorado Boulder · USCornell University · USMorehouse School of Medicine · USAmes Research Center · USBroad Institute · USUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Maryland, Baltimore · USIowa State University · USRice University · USUniversity of Arkansas for Medical Sciences · USColumbia University · USFundação Getulio Vargas · BRGeorgetown University · USJohns Hopkins University · USKBR (United States) · USThe University of Texas MD Anderson Cancer Center · USThe University of Texas Medical Branch at Galveston · USUniversity of Chicago · US
Funding
Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6MThe Role o f Tetrahydrobiopterin (BH4) Bioavailability in Radiation-induced Skin InjuryP20GM109005 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI BOERMA, MARJAN · 2015 to 2024
$21.1MProject 3: Serological Interactions with the Mucosal Innate Immune System Regulates COVID-19 Associated Tissue Damage.U54CA260543 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WOLFGANG, MATTHEW C · 2020 to 2024
$9.8MBlood transcriptomics as CT adjuvant to exclude hemorrhage in acute strokeR01NS112422 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI MELLER, ROBERT · 2020 to 2024
$2.8MEngineering of pan-neutralizing anti-HIV envelope antibodiesR01AI147870 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI SAJADI, MOHAMMAD MOHSENI · 2020 to 2024
$2.5MMechanisms of ASIC-mediated neuronal injuryR01NS104349 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI SIMON, ROGER PANCOAST · 2018 to 2023
$1.6MEpidemiologic Case-control Study of Barrett's EsophagusK23DK059311 · NIDDK · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI SHAHEEN, NICHOLAS J · 2001 to 2005
$626kMacrophage and monocyte TBK1 function in host defense against influenzaK08HL143271 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAGAN, ROBERT STEWART · 2019 to 2021
$535kFunctions of TBK1 in neutrophils during bacterial pneumoniaR03HL155249 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAGAN, ROBERT STEWART · 2021 to 2022
$156kInvestigating the role of ubiquitination in regulating viral RNA processing during Adenovirus infectionF32AI147587 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI DYBAS, JOSEPH M · 2019 to 2020
$133kBiotechnology and Biological Sciences Research Council BB/F00964X/1NCATS NIH HHS UL1 TR002489NCI NIH HHS U54 CA260543NHLBI NIH HHS K08 HL143271NHLBI NIH HHS R03 HL155249NIAID NIH HHS F32 AI147587NIAID NIH HHS R01 AI147870NIDDK NIH HHS K23 DK059311NIGMS NIH HHS P20 GM109005NINDS NIH HHS R01 NS104349NINDS NIH HHS R01 NS112422
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provide an exciting avenue toward antiviral therapeutics. From patient transcriptomic data, we determined that a circulating miRNA, miR-2392, is directly involved with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) machinery during host infection. Specifically, we show that miR-2392 is key in driving downstream suppression of mitochondrial gene expression, increasing inflammation, glycolysis, and hypoxia, as well as promoting many symptoms associated with coronavirus disease 2019 (COVID-19) infection. We demonstrate that miR-2392 is present in the blood and urine of patients positive for COVID-19 but is not present in patients negative for COVID-19. These findings indicate the potential for developing a minimally invasive COVID-19 detection method. Lastly, using in vitro human and in vivo hamster models, we design a miRNA-based antiviral therapeutic that targets miR-2392, significantly reduces SARS-CoV-2 viability in hamsters, and may potentially inhibit a COVID-19 disease state in humans.
Indexed as
AdultAgedAged, 80 and overAnimalsAntiviral AgentsBiomarkersCOVID-19COVID-19 Drug TreatmentCricetinaeFemaleFerretsGene Expression RegulationGlycolysisHealthy VolunteersHumansHypoxiaAntiviral AgentsBiomarkersMicroRNAsMIRN2392 microRNA, humanantiviral therapeuticbiomarkerCOVID-19microRNAmiR-2392miRNAnanoligomersSARS-CoV-2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.