ArticlePloS one2021
The effect of age on the heart rate variability of healthy subjects.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Effectiveness of spinal manipulation in influencing the autonomic nervous system - a systematic review and meta-analysis.The Journal of manual & manipulative therapy · 2024Pooled it
- Heart Rate Variability and Blood Pressure Response to Low-Intensity Endurance Exercise Training Plus Blood Flow Restriction in Individuals with Mild Hypertension: A Randomized Controlled Clinical Trial.Iranian journal of medical sciences · 2025Trial
- Psychobiological Stress Regulation in Depressive Women Achieved Through Group Music Therapy: Results From the Randomised-Controlled Music Therapy for Depression Study.Stress and health : journal of the International Society for the Investigation of Stress · 2025Trial
- Changes in Negative Emotions Across Five Weeks of HRV Biofeedback Intervention were Mediated by Changes in Resting Heart Rate Variability.Applied psychophysiology and biofeedback · 2025Trial
- An open trial of biofeedback for long COVID.Journal of psychosomatic research · 2024Trial
- Pediatric Reference Limits for Holter Monitor Heart Rate Variability Parameters: Defined Using Meta-Analysis.Pediatric cardiology · 2026Article
- Resting State Heart Rate Variability in Depression: An Introductory Narrative Review of Cross-Sectional and Longitudinal Evidence.Journal of personalized medicine · 2026Review
- Observational
- Individual training prescribed by heart rate variability, heart rate and well-being scores in experienced cyclists.Scientific reports · 2025Article
- Effects of Induced Physical Fatigue on Heart Rate Variability in Healthy Young Adults.Sensors (Basel, Switzerland) · 2025Article
- Classification of Individuals With COVID-19 and Post-COVID-19 Condition and Healthy Controls Using Heart Rate Variability: Machine Learning Study With a Near-Real-Time Monitoring Component.Journal of medical Internet research · 2025Article
- Parasympathetic decreases immediately following self-reported cannabis smoking among adults living with cannabis use disorder.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2025Article
- Real-Time Forecasting from Wearable-Monitored Heart Rate Data Through Autoregressive Models.Journal of healthcare informatics research · 2025Article
- Enhancing cardiovascular monitoring: a non-linear model for characterizing RR interval fluctuations in exercise and recovery.Scientific reports · 2025Article
- Effects of Physical Exercise on Cardiometabolic Health in Individuals with Autism Spectrum Disorder: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Optimal frequency bands for pupillography for maximal correlation with HRV.Scientific reports · 2025Article
- Exploring longitudinal physiologic stress measurement and sleep quality interventions to improve psychological well-being in nurses: a pilot study.Health psychology and behavioral medicine · 2025Article
- Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node.Frontiers in medicine · 2025Article
- Age-dependent patterns of cardiac complexity unveiled by topological data analysis of pediatric heart rate variability.PloS one · 2025Article
- Heart rate variability is more sensitive to stress than heart rate in specialist police undergoing selection.PloS one · 2025Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work we study the characteristics of heart rate variability (HRV) as a function of age and gender. Our analysis covers a wider age range than that studied so far. It includes results previously reported in the literature and reveals behaviours not reported before. We can establish basic scale relationships in different HRV measurements. The mean value of the RR intervals shows a power-law behaviour independent of gender. Magnitudes such as the standard deviation or pNN50 show abrupt changes at around the age of 12 years, and above that age they show gender dependence, which mainly affects short-time (or high frequency) scales. We present a unified analysis for the calculation of the non-linear α and β parameters. Both parameters depend on age; they increase in the extremes of life and reach a minimum at around one year of age. These gender-independent changes occur at low frequencies and in scale ranges that depend on age. The results obtained in this work are discussed in terms of the effects of basal metabolic rate, hormonal regulation, and neuronal activity on heart rate variability. This work finally discusses how these findings influence the interpretation of HRV measurements from records of different lengths.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.