Evidence map›Paper›PMID 34623914›Full record

ArticleScience advances2021

MagneTEskin-Reconstructing skin by magnetically induced assembly of autologous microtissue cores.

Christiane Fuchs, Linh Pham, Ying Wang, William A Farinelli, R Rox Anderson, Joshua Tam

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christiane FuchsWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-5052-3198
Linh PhamWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-9754-2492
Ying WangWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-3328-3222
William A FarinelliWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-0972-485X
R Rox AndersonWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Joshua TamWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-1649-3888

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin wounds are immense medical and socioeconomic burdens, and autologous skin grafting remains the gold standard for wound repair. We recently found that full-thickness micro skin tissue columns (MSTCs) can be harvested with minimal donor site morbidity, and that MSTCs applied to wounds “randomly” (without maintaining their natural epidermal-dermal orientation) can accelerate re-epithelialization. However, despite MSTCs containing all the cellular and extracellular contents of full-thickness skin, normal dermal architecture was not restored by random MSTCs. In this study, we developed a magnetically induced assembly method to produce constructs of densely packed, oriented MSTCs that closely resemble the overall architecture of full-thickness skin to test the hypothesis that maintaining MSTCs’ orientation could further hasten healing and restore a normal dermis. Our method led to faster and more orderly re-epithelialization but unexpectedly did not improve the retention of dermal architecture, which reveals a hitherto unappreciated role for tissue morphology in determining dermal remodeling outcomes.

Identifiers

PMID34623914
PMCPMC8500515

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.