Evidence map›Paper›PMID 34623765›Full record

ArticleChemMedChem2022

A Bivalent Supramolecular GCP Ligand Enables Blocking of the Taspase1/Importin α Interaction.

Alexander Höing, Alexander Zimmermann, Lisa Moews, Matthias Killa, Marius Heimann, Astrid Hensel, Jens Voskuhl, Shirley K Knauer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alexander HöingInstitute for Molecular Biology II, Center for Medical Biotechnology (ZMB), University of Duisburg-Essen, Universitätsstrasse 5, 45117, Essen, Germany.ORCID 0000-0002-3762-4832
Alexander ZimmermannFaculty of Chemistry (Organic Chemistry) and CENIDE, University of Duisburg Essen, Universitätsstrasse 7, 45141, Essen, Germany.
Lisa MoewsInstitute for Molecular Biology II, Center for Medical Biotechnology (ZMB), University of Duisburg-Essen, Universitätsstrasse 5, 45117, Essen, Germany.
Matthias KillaFaculty of Chemistry (Organic Chemistry) and CENIDE, University of Duisburg Essen, Universitätsstrasse 7, 45141, Essen, Germany.
Marius HeimannFaculty of Chemistry (Organic Chemistry) and CENIDE, University of Duisburg Essen, Universitätsstrasse 7, 45141, Essen, Germany.
Astrid HenselInstitute for Molecular Biology II, Center for Medical Biotechnology (ZMB), University of Duisburg-Essen, Universitätsstrasse 5, 45117, Essen, Germany.ORCID 0000-0002-0793-0249
Jens VoskuhlFaculty of Chemistry (Organic Chemistry) and CENIDE, University of Duisburg Essen, Universitätsstrasse 7, 45141, Essen, Germany.ORCID 0000-0002-9612-2306
Shirley K KnauerInstitute for Molecular Biology II, Center for Medical Biotechnology (ZMB), University of Duisburg-Essen, Universitätsstrasse 5, 45117, Essen, Germany.ORCID 0000-0003-4321-0924
University of Duisburg-Essen · DE

Funding

DFG collaborative research centre
6 · The paper itself

Abstract

Taspase1 is a unique protease not only pivotal for embryonic development but also implicated in leukemia as well as solid tumors. As such, it is a promising target in cancer therapy, although only a limited number of Taspase1 inhibitors lacking general applicability are currently available. Here we present a bivalent guanidiniocarbonyl-pyrrole (GCP)-containing supramolecular ligand that is capable of disrupting the essential interaction between Taspase1 and its cognate import receptor Importin α in a concentration-dependent manner in vitro with an IC

Indexed as

alpha KaryopherinsDose-Response Relationship, DrugEndopeptidasesGuanidineHumansLigandsMolecular StructureProtease InhibitorsPyrrolesStructure-Activity Relationshipalpha KaryopherinsEndopeptidasesGuanidineLigandsProtease InhibitorsPyrrolestaspase1, humanImportin αnuclear localization signal (NLS)proteaseprotein-interactionSPPSsubstrate cleavage assaysupramolecular inhibitionTaspase1

Identifiers

PMID34623765
PMCPMC9298320
OpenAlexW3204131127

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.