Evidence map›Paper›PMID 34623591›Full record

ArticleInternational urology and nephrology2021

Gleason grade accuracy of transperineal and transrectal prostate biopsies in MRI-naïve patients.

Liang G Qu, Modher Al-Shawi, Tess Howard, Nathan Papa, Cedric Poyet, Brian Kelly, A J Matthew Egan, Nathan Lawrentschuk, Damien Bolton, Gregory S Jack

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Article in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Liang G QuDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, Australia.
Modher Al-ShawiDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, Australia.
Tess HowardDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, Australia.
Nathan PapaDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Cedric PoyetDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, Australia.
Brian KellyDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, Australia.
A J Matthew EganOlivia Newton John Cancer Research Institute, Austin Health, Melbourne, Australia.
Nathan LawrentschukDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, Australia.
Damien BoltonDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, Australia.
Gregory S JackDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, Australia. gregory.jack@austin.org.au.ORCID http://orcid.org/0000-0001-9192-8362

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAccurate assessment of Gleason grade is essential to guiding prostate cancer management. Not all healthcare systems have universal access to prostate MRI. We investigated whether transperineal (TP) prostate biopsies provide more accurate Gleason grading than transrectal (TR) biopsies in MRI-naïve patients.

methodsConsecutive patients undergoing TP and TR systematic prostate needle biopsies from 2011 to 2018 were analysed. Patients who underwent radical prostatectomy (RP) within 180 days of biopsies were included. Patients undergoing MRI prior to biopsies were excluded. Pathological concordance, incidence of Gleason upgrading, and correlation coefficients among biopsies and RP Gleason grade were compared. A sub-analysis for concordance in anterior prostate tumours was conducted.

results262 patients were included (112 TP; 150 TR), the median age was 63 years, and median time from biopsy to RP was 68 days. Concordance with RP histology for TP was 65% compared to 49% for TR (p = 0.011). Biopsy technique predicted RP concordance independent of the number of cores. Gleason upgrading occurred following 24% of TP versus 33% of TR biopsies. In anterior and apical tumours, upgrading occurred in 19% of TP biopsies and 38% of TR biopsies (p = 0.027).

conclusionThis study suggests TP approach to prostate biopsies result in improved histological grade accuracy in men whom MRI is not available, even after controlling for number of cores. TP approach also resulted in less upgrading for lesions in the anterior and apical prostate compared to TR.

Indexed as

Biopsy, NeedleHumansMagnetic Resonance ImagingMaleMiddle AgedNeoplasm GradingProstatectomyProstatic NeoplasmsGleason scoreGleason upgradingProstate cancerTemplate biopsyTransperineal

Identifiers

PMID34623591

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.