Trial reportClinical oral investigations2022
Local application of hyaluronic acid in conjunction with free gingival graft: a randomized clinical trial.
Trial report in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07458685 (Efficacy of Cross-linked Hyaluronic Acid in Improving Healing After Free Gingival Graft), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Cross-linked Hyaluronic Acid in Improving Healing After Free Gingival Graft: a Randomized Controlled Clinical Trial
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Postoperative pain and morbidity at the donor site after palatal soft tissue harvesting: a systematic review.BMC oral health · 2025Pooled it
- Postoperative pain control after free gingival graft: a systematic review and meta-analysis of RCTS.Brazilian dental journal · 2025Pooled it
- Effect of Hyaluronic Acid on Palatal Wound Healing-A Randomized Crossover Clinical Trial.Clinical oral implants research · 2026Trial
- The Effect of injectable platelet-rich fibrin and low-level laser therapy on graft shrinkage in free gingival grafts: a randomized controlled clinical trial.BMC oral health · 2026Trial
- Comparative evaluation of hyaluronic acid and injectable platelet-rich fibrin in palatal wound healing: a randomized clinical trial.BMC oral health · 2025Trial
- Palatal donor site management using tissue adhesives with adjunctive coconut oil in a randomized clinical trial.Scientific reports · 2025Trial
- The effect of Polyvinylpyrrolidone-Sodium hyaluronate gel on palatal wound healing: a randomized controlled clinical trial.BMC oral health · 2025Trial
- Comparison of conventional and modified sling suture techniques in free gingival graft operations-a randomized controlled clinical trial.BMC oral health · 2025Trial
- Clinical and Patient-Reported Outcome Measures of Palatal Donor Site Healing Using Polyvinylpyrrolidone-Sodium Hyaluronate Gel as a Dressing Material Following Free Gingival Graft Harvesting: A Randomized Controlled Clinical Trial.Clinical and experimental dental research · 2024Trial
- Effect of a gel containing green tea extract and hyaluronic acid on palate pain scores and wound healing after free gingival graft: a quasi-randomized controlled clinical trial.Clinical oral investigations · 2023Trial
- Efficacy of different interventions on the morbidity of the palatal donor area after free gingival graft and connective tissue graft: A systematic review.The Japanese dental science review · 2025Review
- Bioactive materials for post-operative healing and pain relief following palatal epithelialized graft harvesting: A meta-analysis of randomized clinical trials.Journal of dental sciences · 2025Article
- Postoperative local interventions for the palate as a gingival graft donor area: a scoping review.Clinical oral investigations · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the effect of the application of hyaluronic acid (HA) in conjunction with free gingival graft (FGG) on postoperative patient discomfort and wound healing. MATERIALS AND
methodsA total of 24 healthy non-smoker patients requiring FGG were recruited for the study. Subjects were randomly assigned into study groups, local application of HA on both donor and recipient sites and control group, application of normal saline. The FGG dimensions were evaluated using digital photographs. Post-operative pain was evaluated for 14 days. Color matching and patient satisfaction were evaluated at 6 months.
resultsIn this randomized clinical trial, 21 patients (mean age 23 years, (15 females and 6 males) completed the study. Baseline characteristics were comparable across treatment groups. Pain scores in donor sites were statistically significant and higher in control group than study group until day 7 (p < 0.05). Mean of the surface area of the graft at baseline in study vs control group were (169 ± 21), (183 ± 22) (2 mm), respectively. While at 6 months, were (147 ± 30) and (139 ± 32) (2 mm), in study and control group, respectively (p > 0.05). Color match showed no statistical significance difference.
conclusionsTopical application of HA may exhibit significant improvement of postoperative pain and no significant difference in graft dimensions and patients' satisfaction. CLINICAL RELEVANCE: Topical application of HA is recommended as a dressing material in FGG surgeries to reduce postoperative pain and accelerate healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.