ArticleScandinavian journal of work, environment & health2022
Changes in melatonin and sex steroid hormone production among men as a result of rotating night shift work - the HORMONIT study.
Article in Scandinavian journal of work, environment & health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Association between night shift work and the risk of type 2 diabetes mellitus: a cohort-based meta-analysis.BMC endocrine disorders · 2024Pooled it
- Shift Work, Circadian Disruption, and Immune Dysregulation: Molecular Links to Gastrointestinal Diseases and Occupational Health Implications.Diagnostics (Basel, Switzerland) · 2026Review
- Night shift work and breast cancer risk - 2023 update of epidemiologic evidence.Journal of the National Cancer Center · 2025Review
- Night shift work and prostate cancer: a large cohort study from UK Biobank and Mendelian randomisation study.BMJ open · 2024Article
- Circadian de(regulation) in physiology: implications for disease and treatment.Genes & development · 2024Review
- Identification of Predictors of Shift Work Adaptation and Its Association With Immune, Hormonal and Metabolite Biomarkers.Journal of pineal research · 2024Article
- Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management.Molecular neurobiology · 2024Review
- The association between shift work, shift work sleep disorders and premature ejaculation in male workers.BMC public health · 2024Article
- Guanxin V alleviates ventricular remodeling after acute myocardial infarction with circadian disruption by regulating mitochondrial dynamics.Sleep & breathing = Schlaf & Atmung · 2024Article
- Night and shift work patterns and incidence of type 2 diabetes and hypertension in a prospective cohort study of healthcare employees.Scandinavian journal of work, environment & health · 2023Article
- Alterations in Pregnenolone and Testosterone Levels in Male Shift Workers.International journal of environmental research and public health · 2023Article
- Metabolic profiling of night shift work - The HORMONIT study.Chronobiology international · 2022Article
- Disruption of cellular immune response among male rotating night shift workers in Spain- The HORMONIT study.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveData from real world settings on circadian disruption and subsequent hormone-related changes may explain the higher risk of hormone-dependent cancers among night shift workers.The present study examines the melatonin and sex steroid hormone levels among night shift workers.
methodsWe included 44 male, rotating shift workers from a car factory in Spain, sampled both at the end of a 3-week night shift (22:00-06:00 hrs) and a 3-week early morning shift (06:00-14:00 hrs). Participants collected all urine voids over 24-hours during each shift. Urinary concentrations of sex steroid hormones (estrogens, androgens and progestogens) and 6-sulfatoxymelatonin (aMT6s, major melatonin metabolite) were determined. Individual cosinor analysis was used to derive the acrophase (peak time) and area under the curve (total production). Linear mixed models examined intraindividual associations between night shift work and log-transformed 24-hour peak time and total production of hormones compared to early morning shift work.
resultsThe acrophase was delayed during the night shift for aMT6s [geometric mean difference (GMD) 7.53 hrs, 95% confidence interval (CI) 4.46-10.60], androgens (eg, testosterone: GMD 6.83 hrs, 95% CI 0.34-13.32) and progestogens (eg, 17-hydroxyprogesterone: GMD 4.54 hrs, 95% CI 2.92-6.16) compared to the early morning shift. We found a higher production of adrenal androgen 11-oxoandrosterone/11-oxoetiocholanolone [geometric mean ratio (GMR) 1.43, 95% CI 1.12-1.81], and a lower production of adrenal progestogen 16-cysteinylprogesterone (GMR 0.79, 95% CI 0.67-0.93) during the night shift compared to the early morning shift levels.
conclusionsNight shift work was associated with melatonin and sex hormone-related changes in timing and total production, providing insight into the mechanistic path for its association with hormone-dependent cancer.
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