ArticleThe Journal of infectious diseases2022
Recommendations for Screening and Diagnosis of Chagas Disease in the United States.
Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- The efficacy and safety of benznidazole in adults with seropositive indeterminate form, Trypanosoma cruzi infection: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Article
- Policy Recommendations for Chagas Disease: An Emerging Concern of Public Health Significance for the U.S. Military.The American journal of tropical medicine and hygiene · 2026Article
- Chagas Cardiomyopathy in the United States: Testing and Diagnosis Across Real-World Datasets.The American journal of cardiology · 2026Article
- Barriers to Chagas Disease Screening among Primary Care Providers in the United States.The American journal of tropical medicine and hygiene · 2026Article
- Pre-existing anti-polyethylene glycol antibodies in pregnant women and newborns.Journal of nanobiotechnology · 2026Observational
- Catch-Up Screening to Improve Detection of Congenital Chagas Disease in a Nonendemic Setting.The American journal of tropical medicine and hygiene · 2026Article
- You evaluation of the PARACHUTE-HF trial: role of sacubitril/valsartan compared to enalapril on outcomes in patients with heart failure from Chagas' disease.Heart failure reviews · 2026Review
- A Trypanosoma cruzi trans-sialidase peptide demonstrates high serological prevalence among infected populations across endemic regions.The Journal of clinical investigation · 2026Article
- Article
- Chagas Disease: An Opportunistic Infection in AIDS.Current infectious disease reports · 2026Article
- Chagas disease.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025Article
- The Role of Multimodality Cardiac Imaging in the Diagnosis and Management of Chronic Chagas Cardiomyopathy.JACC. Case reports · 2025Article
- Non-Coding RNAs as Emerging Biomarkers in Leishmaniasis and Chagas Disease.Tropical medicine and infectious disease · 2025Review
- Case Report: Donor-derived Chagas Disease Post-heart Transplant After False-negative DonorTransplantation direct · 2025Article
- Serology-Based Screening and Prevalence of Schistosomiasis, Strongyloidiasis, and Chagas Disease in Migrants Living with HIV: Results from a 10-Year Retrospective Cohort in an Italian Tertiary Healthcare Center.Tropical medicine and infectious disease · 2025Article
- Chagas Disease in Northern California: Observed Prevalence, Clinical Characteristics, and Outcomes Within an Integrated Health Care Delivery System.The Permanente journal · 2025Article
- Outcomes in Military Blood Donors at Joint Base San Antonio With ReactiveOpen forum infectious diseases · 2025Article
- An Evidence-Based Intervention to IncreaseOpen forum infectious diseases · 2025Article
- Chagas disease screening of maternal donors in publicly banked umbilical cord blood in North Carolina, United States 2007-2023.Pregnancy (Hoboken, N.J.) · 2025Article
Corrections and comments
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Authors and funding
15 authors at 10 institutions in 1 country.
Funding
Abstract
backgroundChagas disease affects an estimated 326 000-347 000 people in the United States and is severely underdiagnosed. Lack of awareness and clarity regarding screening and diagnosis is a key barrier. This article provides straightforward recommendations, with the goal of simplifying identification and testing of people at risk for US healthcare providers.
methodsA multidisciplinary working group of clinicians and researchers with expertise in Chagas disease agreed on 6 main questions, and developed recommendations based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, after reviewing the relevant literature on Chagas disease in the United States.
resultsIndividuals who were born or resided for prolonged time periods in endemic countries of Mexico and Central and South America should be tested for Trypanosoma cruzi infection, and family members of people who test positive should be screened. Women of childbearing age with risk factors and infants born to seropositive mothers deserve special consideration due to the risk of vertical transmission. Diagnostic testing for chronic T. cruzi infection should be conducted using 2 distinct assays.
conclusionsIncreasing provider-directed screening for T. cruzi infection is key to addressing this neglected public health challenge in the United States.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.