Evidence map›Paper›PMID 34623181›Full record

GuidelineAmerican journal of physiology. Heart and circulatory physiology2021

Guidelines for in vivo mouse models of myocardial infarction.

Merry L Lindsey, Keith R Brunt, Jonathan A Kirk, Petra Kleinbongard, John W Calvert, Lisandra E de Castro Brás, Kristine Y DeLeon-Pennell, Dominic P Del Re, Nikolaos G Frangogiannis, Stefan Frantz and 8 more

Open access · greenAbstract readGuidelineReview
In one paragraph

Guideline in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 135 citations in OpenAlex.

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  12. Cellular and molecular signals of cardiac wound healing after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2026
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 18 institutions in 4 countries.

Merry L LindseyDepartment of Cellular and Integrative Physiology, Center for Heart and Vascular Research, University of Nebraska Medical Center, Omaha, Nebraska.ORCID 0000-0002-4090-0391
Keith R BruntDepartment of Pharmacology, Faculty of Medicine, Dalhousie University, Saint John, New Brunswick, Canada.ORCID 0000-0002-5728-8135
Jonathan A KirkDepartment of Cell and Molecular Physiology, Loyola University Chicago Stritch School of Medicine, Chicago, Illinois.ORCID 0000-0002-5192-2860
Petra KleinbongardInstitute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, Essen, Germany.ORCID 0000-0003-3576-3772
John W CalvertCarlyle Fraser Heart Center of Emory University Hospital Midtown, Atlanta, Georgia.
Lisandra E de Castro BrásDepartment of Physiology, The Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Kristine Y DeLeon-PennellDivision of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.ORCID 0000-0002-9647-6112
Dominic P Del ReDepartment of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey.
Nikolaos G FrangogiannisDivision of Cardiology, Department of Medicine, The Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, New York.
Stefan FrantzDepartment of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.
Richard J GuminaDivision of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio.ORCID 0000-0001-8298-1129
Ganesh V HaladeDivision of Cardiovascular Sciences, Department of Medicine, University of South Florida, Tampa, Florida.ORCID 0000-0002-5351-9354
Steven P JonesDepartment of Medicine, Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky.ORCID 0000-0001-5376-8089
Rebecca H RitchieDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Victoria, Australia.ORCID 0000-0002-8610-0058
Francis G SpinaleCardiovascular Translational Research Center, University of South Carolina School of Medicine and the Columbia Veteran Affairs Medical Center, Columbia, South Carolina.ORCID 0000-0003-0529-5605
Edward B ThorpDepartment of Pathology and Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Crystal M RipplingerDepartment of Pharmacology, University of California Davis School of Medicine, Davis, California.ORCID 0000-0002-9908-4106
Zamaneh KassiriDepartment of Physiology, Cardiovascular Research Center, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-9357-0912
Albert Einstein College of Medicine · USDalhousie University · CAEast Carolina University · USEmory University · USLoyola University Chicago · USMedical University of South Carolina · USMonash University · AUNorthwestern University · USRutgers, The State University of New Jersey · USThe Ohio State University Wexner Medical Center · USUniversitätsklinikum Würzburg · DEUniversity of Alberta · CAUniversity of California, Davis · USUniversity of Louisville · USUniversity of South Carolina · USUniversity of South Florida · USVA Nebraska Western Iowa Health Care System · USWest German Heart and Vascular Center Essen · DE

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ZHANG, YING · 2016 to 2025
$42.8M
Tumor Necrosis Factor Modulation of CPCsP01HL078825 · NHLBI · UNIVERSITY OF LOUISVILLE · PI BOLLI, ROBERTO · 2005 to 2021
$37.6M
Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
Chemokines in Healing Myocardial InfarctsR01HL076246 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Nikolaos G Frangogiannis · 2005 to 2026
$9.5M
Resolution of Inflammation in healing Myocardial InfarctsR01HL085440 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI FRANGOGIANNIS, NIKOLAOS G · 2008 to 2025
$8.5M
The Role of Adrenergic Stimulation in ArrhythmogenesisR01HL111600 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Crystal May Ripplinger · 2012 to 2026
$7.1M
TBDP30GM127607 · NIGMS · UNIVERSITY OF LOUISVILLE · PI JONES, STEVEN P · 2018 to 2022
$6.3M
Efferocytosis-Directed Inflammation Resolution and Repair in the Hypoxic HeartR01HL122309 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI THORP, EDWARD BENJAMIN · 2014 to 2024
$5.0M
Targeting the orphan nuclear receptor LRH-1 with small moleculesR01DK115213 · NIDDK · EMORY UNIVERSITY · PI John Winter Calvert, Eric A Ortlund · 2017 to 2026
$4.6M
GSK-3β Localizes to the Myofilament and Modifies its Function in Ischemic CardiomyopathyR01HL136737 · NHLBI · UNIVERSITY OF CHICAGO · PI JONATHAN A KIRK · 2017 to 2026
$4.5M
UCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3M
Biosynthetic Pathways in Cardiac RemodelingR01HL147844 · NHLBI · UNIVERSITY OF LOUISVILLE · PI HILL, BRADFORD GUY, JONES, STEVEN P · 2019 to 2022
$3.0M
BLRD VA I01 BX000168BLRD VA I01 BX000505BLRD VA IK2 BX003922NHLBI NIH HHS P01 HL078825NHLBI NIH HHS R01 HL076246NHLBI NIH HHS R01 HL085440NHLBI NIH HHS R01 HL111600NHLBI NIH HHS R01 HL122309NHLBI NIH HHS R01 HL127442NHLBI NIH HHS R01 HL130972NHLBI NIH HHS R01 HL132989NHLBI NIH HHS R01 HL136737NHLBI NIH HHS R01 HL136915NHLBI NIH HHS R01 HL137319NHLBI NIH HHS R01 HL144788NHLBI NIH HHS R01 HL147570NHLBI NIH HHS R01 HL147844NHLBI NIH HHS R01 HL149407NHLBI NIH HHS R01 HL152297NHLBI NIH HHS R25 HL145817NHLBI NIH HHS R56 HL152297NHLBI NIH HHS T32 HL007444NIAAA NIH HHS R21 AA027625NIDDK NIH HHS R01 DK115213NIDDK NIH HHS R56 DK115213NIGMS NIH HHS P30 GM127607NIGMS NIH HHS U54 GM115458NIH HHS S10 OD010417
6 · The paper itself

Abstract

Despite significant improvements in reperfusion strategies, acute coronary syndromes all too often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to remodeling of the left ventricle (LV), the development of LV dysfunction, and ultimately progression to heart failure (HF). Accordingly, an improved understanding of the underlying mechanisms of MI remodeling and progression to HF is necessary. One common approach to examine MI pathology is with murine models that recapitulate components of the clinical context of acute coronary syndrome and subsequent MI. We evaluated the different approaches used to produce MI in mouse models and identified opportunities to consolidate methods, recognizing that reperfused and nonreperfused MI yield different responses. The overall goal in compiling this consensus statement is to unify best practices regarding mouse MI models to improve interpretation and allow comparative examination across studies and laboratories. These guidelines will help to establish rigor and reproducibility and provide increased potential for clinical translation.

Indexed as

Heart FailureMyocardial InfarctionMyocardial Reperfusion InjuryAnimalsBiomedical ResearchConsensusDisease Models, AnimalDisease ProgressionFemaleMaleMiceReperfusionSex FactorsSpecies Specificitycardiacischemia-reperfusionmyocardial infarctionrigor and reproducibilityrodent

Identifiers

PMID34623181
PMCPMC8834230
OpenAlexW3203729610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.