Evidence map›Paper›PMID 34622802›Full record

ArticleJCI insight2021

Macrophages exert homeostatic actions in pregnancy to protect against preterm birth and fetal inflammatory injury.

Nardhy Gomez-Lopez, Valeria Garcia-Flores, Peck Yin Chin, Holly M Groome, Melanie T Bijland, Kerrilyn R Diener, Roberto Romero, Sarah A Robertson

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 79 citations in OpenAlex.

  1. Altered Distribution of CD14American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
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  12. Exosomal Delivery of Interleukin-10 Reduces Infection-Associated Inflammation in a 3D-Printed Model of a Humanized Feto-Maternal Interface.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Nardhy Gomez-LopezRobinson Research Institute and Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
Valeria Garcia-FloresPerinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, US Department of Health and Human Services; Bethesda, Maryland, and Detroit, Michigan, USA.
Peck Yin ChinRobinson Research Institute and Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
Holly M GroomeRobinson Research Institute and Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
Melanie T BijlandRobinson Research Institute and Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
Kerrilyn R DienerRobinson Research Institute and Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
Roberto RomeroPerinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, US Department of Health and Human Services; Bethesda, Maryland, and Detroit, Michigan, USA.
Sarah A RobertsonRobinson Research Institute and Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
The University of Adelaide · AUWayne State University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity of South Australia · AU

Funding

NICHD NIH HHS HHSN275201300006C
6 · The paper itself

Abstract

Macrophages are commonly thought to contribute to the pathophysiology of preterm labor by amplifying inflammation - but a protective role has not previously been considered to our knowledge. We hypothesized that given their antiinflammatory capability in early pregnancy, macrophages exert essential roles in maintenance of late gestation and that insufficient macrophages may predispose individuals to spontaneous preterm labor and adverse neonatal outcomes. Here, we showed that women with spontaneous preterm birth had reduced CD209+CD206+ expression in alternatively activated CD45+CD14+ICAM3- macrophages and increased TNF expression in proinflammatory CD45+CD14+CD80+HLA-DR+ macrophages in the uterine decidua at the materno-fetal interface. In Cd11bDTR/DTR mice, depletion of maternal CD11b+ myeloid cells caused preterm birth, neonatal death, and postnatal growth impairment, accompanied by uterine cytokine and leukocyte changes indicative of a proinflammatory response, while adoptive transfer of WT macrophages prevented preterm birth and partially rescued neonatal loss. In a model of intra-amniotic inflammation-induced preterm birth, macrophages polarized in vitro to an M2 phenotype showed superior capacity over nonpolarized macrophages to reduce uterine and fetal inflammation, prevent preterm birth, and improve neonatal survival. We conclude that macrophages exert a critical homeostatic regulatory role in late gestation and are implicated as a determinant of susceptibility to spontaneous preterm birth and fetal inflammatory injury.

Indexed as

AdultAnimalsAnimals, NewbornCD11b AntigenCytokinesDeciduaFemaleFetal DiseasesFetusHomeostasisHumansInflammationMacrophagesMiceMyometriumObstetric Labor, PrematureCD11b AntigenCytokinesTNF protein, humanTumor Necrosis Factor-alphaCytokinesMacrophagesObstetrics/gynecologyReproductive Biology

Identifiers

PMID34622802
PMCPMC8525593
OpenAlexW3204931394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.