ArticleeLife2021
Memory recall involves a transient break in excitatory-inhibitory balance.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Memory impairment and chronic high-dose Δ9-THC/cannabis exposure: a narrative review of molecular mechanisms underlying neurotoxic effects.Psychopharmacology · 2026Review
- Human short-term memory learning based on dynamic glutamate levels and oscillatory activities: concurrent metabolic and electrophysiological studies using event-related functional-MRS and EEG modalities.Cognitive processing · 2026Article
- Article
- Noradrenaline causes a spread of association in the hippocampal cognitive map.Nature communications · 2026Article
- The Tip-of-the-Tongue Phenomenon: Cognitive, Neural, and Neurochemical Perspectives.Biomedicines · 2026Review
- Excitation-inhibition homeostasis in Alzheimer's disease: a selective multiscale review of mechanisms, sex differences, and therapeutic opportunities.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Unconscious switching of dorsal and medial pathways for plasticity and stability during NREM and REM sleep.bioRxiv : the preprint server for biology · 2025Article
- Chronic Styrene Exposure Causes Oxidative Stress, Neuroinflammation, and Hippocampal Memory Dysfunction via NLRP3 Inflammasome Activation.Molecular neurobiology · 2025Article
- A compressed code for memory discrimination.bioRxiv : the preprint server for biology · 2025Article
- Incremental self-organization of spatio-temporal spike pattern detection.Scientific reports · 2025Article
- Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex.Science advances · 2025Article
- Compensatory Regulation of Excitation/Inhibition Balance in the Ventral Hippocampus: Insights from Fragile X Syndrome.Biology · 2025Review
- The role of memory in affirming-the-consequent fallacy.iScience · 2025Article
- Challenges of Investigating Compartmentalized Brain Energy Metabolism Using Nuclear Magnetic Resonance Spectroscopy in vivo.Neurochemical research · 2025Review
- Unveiling Glutamate Dynamics: Cognitive Demands in Human Short-Term Memory Learning Across Frontal and Parieto-Occipital Cortex: A Functional MRS Study.Journal of biomedical physics & engineering · 2024Article
- MRS-assessed brain GABA modulation in response to task performance and learning.Behavioral and brain functions : BBF · 2024Review
- Recurrent inhibition refines mental templates to optimize perceptual decisions.Science advances · 2024Article
- Sleep-dependent engram reactivation during hippocampal memory consolidation associated with subregion-specific biosynthetic changes.iScience · 2024Article
- Plasticity-stability dynamics during post-training processing of learning.Trends in cognitive sciences · 2024Review
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The brain has a remarkable capacity to acquire and store memories that can later be selectively recalled. These processes are supported by the hippocampus which is thought to index memory recall by reinstating information stored across distributed neocortical circuits. However, the mechanism that supports this interaction remains unclear. Here, in humans, we show that recall of a visual cue from a paired associate is accompanied by a transient increase in the ratio between glutamate and GABA in visual cortex. Moreover, these excitatory-inhibitory fluctuations are predicted by activity in the hippocampus. These data suggest the hippocampus gates memory recall by indexing information stored across neocortical circuits using a disinhibitory mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.