ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2021
[Preparation of Antibiotic-Loaded Copper-Doped Hydroxyapatite Microspheres and Evaluation of Their Antibacterial and Osteogenic Effect].
Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 1 citations in OpenAlex.
- Polydopamine-Based Biomaterials in Orthopedic Therapeutics: Properties, Applications, and Future Perspectives.Drug design, development and therapy · 2024Review
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the preparation method of copper (Cu)-doped hydroxyapatite (HA) microspheres loaded with vancomycin (Van), and evaluate their antibacterial and osteogenic effects
methodsThe Cu doped HA microspheres (Cu-HA) with molar doping ratios of 1%, 5%, 10%, and 20% were prepared by hydrothermal synthesis. The microscopic morphology changes were observe with scanning electron microscope. X-ray diffractometer (XRD) was used to study the phase composition and analyze the crystallinity of the sample. Cu-HA with a molar doping ratio of 10% was selected for analysis of the elemental composition of the sample with energy dispersive X-ray spectroscopy (EDS), and was then coated with polydopamine (PDA) as the medium to prepare Cu-HA-PDA. XRD and Fourier infrared spectrometer were used to examine the coating effect of the sample. Van was load on Cu-HA-PDA to prepare Cu-HA-PDA-Van. HA, Cu-HA, HA-PDA, and Cu-HA-PDA-Van were added to α medium at 10 mg/mL to prepare different groups of extract solutions.The main components of the extract solutions were examined, and the Van concentration was checked. We examined the toxic effect of material extract solutions on osteogenic precursor cells and the proliferation and differentiation of bone marrow mesenchymal stem cells, and checked the expression of osteocalcin (
resultsVarious types of Cu-doped HA (Cu-HA) were successfully synthesized. As the proportion of Cu increased, the morphology gradually changed from being strip or belt-shaped to a uniform spherical shape. Cu-HA of 10% molar doping ratio showed a clearly microspherical shape and a petal-like porous micro-nano morphology on the surface. EDS and XRD analyses showed that the main structure of the material was still made up of hydroxyapatite crystals and Cu was successfully doped with HA. The infrared spectrometer showed that the PDA was successfully coated on the surface of the material. Examination of the main components of the extract solution once again verified that the Cu element had successfully entered and replaced part of the Ca element in the HA. The 10 mg/mL Cu-HA-PDA-Van extract solution contained 0.27 mg/mL of Van.
conclusionCu element was used to control the microscopic morphology of HA, and the Cu-HA-PDA-Van microspheres prepared by successfully coating of PDA and loading of Van had good antibacterial properties and biological activity.
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