ArticleAmerican journal of medical genetics. Part A2022
Causes of death in patients with Down syndrome in 2014-2016: A population study in Japan.
Article in American journal of medical genetics. Part A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Death in People with Down syndrome: Mortality statistics and novel predictors in US Medicaid and Medicare enrolled adults.medRxiv : the preprint server for health sciences · 2026Article
- Immediate and Underlying Causes of Death and Survival Rates in Aging Adults With Down Syndrome.Journal of applied research in intellectual disabilities : JARID · 2026Article
- Factors impacting survival in individuals with Down syndrome-associated Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Hospitalizations in people with down syndrome across age groups: a population-based cohort study in Switzerland.EClinicalMedicine · 2025Article
- Death of children with Down syndrome by gestational age and cause.Pediatric research · 2024Article
- Senescent hearts from male Ts65Dn mice exhibit preserved function but altered size and nicotinamide adenine dinucleotide pathway signaling.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- A French nationwide study compared various conditions and healthcare use of individuals < 65 years with a Down's syndrome to those without.Scientific reports · 2023Article
- Congenital leukemia: A case report and review of literature.World journal of clinical cases · 2023Article
- Breathing and Oxygen Carrying Capacity in Ts65Dn and Down Syndrome.Function (Oxford, England) · 2023Article
- Causes of death in patients with Down syndrome in 2014-2016: A population study in Japan.American journal of medical genetics. Part A · 2022Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the higher mortality rates in patients with Down syndrome compared with the general Japanese population, the life span has dramatically increased in Japan and other countries. We aimed to clarify recent causes of death in patients with Down syndrome in Japan. We calculated proportionate mortality and standardized mortality odds ratios (SMORs) among all deaths registered with Down syndrome as the cause of death (ICD-10 code, Q90) in the Japanese National Death Registry Database in 2014-2016. In the study period, 762 in patients with Down syndrome died. The main causes of death were pneumonia/respiratory infections (20.5%), congenital malformations of the circulatory system (11.2%), other diseases of the circulatory system (9.2%), and aspiration pneumonia (8.4%). The SMORs (95% confidence intervals) were higher for natural death, defined as death of an elderly person with no other cause of death to be mentioned (55.73 [36.92-84.12]), early-onset Alzheimer's disease, defined as Alzheimer's disease with onset <65 years of age (29.36 [16.44-52.44]), aspiration pneumonia (18.33 [14.03-23.96]), pneumonia/respiratory infections (8.11 [6.76-9.73]), congenital malformations of the circulatory system (8.07 [5.98-10.88]), and leukemia/lymphoma (2.16 [1.55-2.99]) but lower for malignant solid tumors (0.04 [0.02-0.06]) in patients with Down syndrome. Patients with Down syndrome had the greatest relative risk of dying from natural death, early-onset Alzheimer's disease, and respiratory illnesses, highlighting the need for appropriate medical, health, and welfare services.
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