Evidence map›Paper›PMID 34622433›Full record

ArticleCardiology journal2022

Low-dose ticagrelor with or without acetylsalicylic acid in patients with acute coronary syndrome: Rationale and design of the ELECTRA-SIRIO 2 trial.

Jacek Kubica, Piotr Adamski, Diana A Gorog, Aldona Kubica, Bernd Jilma, Andrzej Budaj, Jolanta M Siller-Matula, Paul A Gurbel, Dimitrios Alexopoulos, Jolita Badarienė and 26 more

Registry-linked trialAbstract read
In one paragraph

Article in Cardiology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04755387 (EASTYLE), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04755387 phase4recruitingnot on this mapstarted 2023, after this paper: background citation

EASTYLE (DE-escAlation Strategy for Optimal Ticagrelor Therapy in Acute MYocardiaL Infarction PatiEnts, Prospective, Multicenter, Randomized) Trial

TypeinterventionalSponsorDong-A UniversityRan2023 to 2028Enrolled2,312ConditionsAcute Myocardial InfarctionArmsDe-escalation strategy, Conventional strategy
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Jacek KubicaCollegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.ORCID 0000-0001-8250-754X
Piotr AdamskiCollegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland. piotr.adamski@wp.eu.ORCID 0000-0001-9719-0987
Diana A GorogPostgraduate Medical School, University of Hertfordshire, Stevenage, United Kingdom.
Aldona KubicaCollegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.ORCID 0000-0002-4608-0881
Bernd JilmaDepartment of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland, Austria.
Andrzej BudajCenter of Postgraduate Medical Education, Grochowski Hospital, Warsaw, Poland.
Jolanta M Siller-MatulaDepartment of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland, Austria.
Paul A GurbelSinai Center for Thrombosis Research and Drug Development, Sinai Hospital, Life Bridge Health System, Baltimore, MD, United States.
Dimitrios AlexopoulosNational and Kapodistrian University of Athens Medical School, Attikon University Hospital, Athens, Greece.
Jolita BadarienėClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Paweł DąbrowskiDepartment of Cardiology, The Pope John Paul II Hospital, Zamosc, Poland.
Dariusz DudekInstitute of Cardiology, Jagiellonian University Medical College, Krakow, Poland.
Evangelos GiannitsisMedizinische Klinik III, Department of Cardiology, Angiology and Pulmology, University Hospital of Heidelberg, Germany.
Grzegorz HorszczarukDepartment of Cardiology, Voivodeship Hospital, Lomza, Poland.
Miłosz J Jaguszewski1st Department of Cardiology, Medical University of Gdansk, Poland.
Stefan JamesDepartment of Medical Sciences and Uppsala Clinical Research Center, Uppsala University Hospital, Uppsala, Sweden.
Young-Hoon JeongDepartment of Internal Medicine, Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon, South Korea.
Michał KryjakDepartment of Cardiology, The Doctor Sokolowski Hospital, Walbrzych, Poland.
Piotr NiezgodaCollegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Małgorzata OstrowskaCollegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Giuseppe PattiUniversity of Eastern Piemont, Maggiore della Carità Hospital, Novara, Italy.
Janusz RomanekCardiology Department with the Acute Coronary Syndromes Subdivision, Clinical Provincial Hospital No. 2, Faculty of Medicine, University of Rzeszow, Poland.
Salvatore Di SommaDepartment of Medical-Surgery Sciences and Translational Medicine, University La Sapienza, Rome, Italy.
Giuseppe SpecchiaPavia, Italy.
Udaya TantrySinai Center for Thrombosis Research and Drug Development, Sinai Hospital, Life Bridge Health System, Baltimore, MD, United States.
Mariusz Gąsior3rd Department of Cardiology, Silesian Center for Heart Diseases, Faculty of Medicine in Zabrze, Medical University of Silesia, Zabrze, Poland.
Agnieszka TycińskaDepartment of Cardiology, Medical University of Bialystok, Poland.
Wojciech WojakowskiDivision of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland.
Katarzyna BuszkoCollegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Robert GilDepartment of Invasive Cardiology, Center of Postgraduate Medical Education, Central Hospital of the Internal Affairs and Administration Ministry, Warsaw, Poland.
Marcin Gruchała1st Department of Cardiology, Medical University of Gdansk, Poland.
Jarosław Kasprzak1st Department and Chair of Cardiology, Medical University of Lodz, Bieganski Hospital, Lodz, Poland.
Andrzej KleinrokDepartment of Cardiology, The Pope John Paul II Hospital, Zamosc, Poland.
Jacek LegutkoDepartment of Interventional Cardiology, Institute of Cardiology, Jagiellonian University Medical College and John Paul II Hospital in Krakow, Poland.
Maciej LesiakChair and 1st Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
Eliano P NavareseCollegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acute Coronary SyndromePercutaneous Coronary InterventionAspirinCarbidopaDrug CombinationsHumansLevodopaPlatelet Aggregation InhibitorsTicagrelorTreatment OutcomeAspirinCarbidopaDrug CombinationsLevodopaPlatelet Aggregation InhibitorssirioTicagrelor

Identifiers

PMID34622433
PMCPMC8890404

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.