Evidence map›Paper›PMID 34622427›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2022

Differential Distribution of Tryptophan-Metabolites in Fetal and Maternal Circulations During Normotensive and Preeclamptic Pregnancies.

Ying-Jie Zhao, Chi Zhou, Ying-Ying Wei, Hui-Hui Li, Wei Lei, Derek S Boeldt, Kai Wang, Jing Zheng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Tryptophan's Journey Through Pregnancy: The Role of Serotonin.International journal of tryptophan research : IJTR · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Observational
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  15. Article
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  18. Review
  19. The Function of the Kynurenine Pathway in the Placenta: A Novel Pharmacotherapeutic Target?International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ying-Jie Zhao *Department of Obstetrics and Gynecology, University of Wisconsin-Madison, PAB1 UnityPoint Health-Meriter Hospital, 202 S. Park Street, Madison, WI, 53715, USA.
Chi Zhou *Department of Obstetrics and Gynecology, University of Wisconsin-Madison, PAB1 UnityPoint Health-Meriter Hospital, 202 S. Park Street, Madison, WI, 53715, USA.
Ying-Ying WeiShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Hui-Hui LiDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, PAB1 UnityPoint Health-Meriter Hospital, 202 S. Park Street, Madison, WI, 53715, USA.
Wei LeiCardiovascular Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Derek S BoeldtDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, PAB1 UnityPoint Health-Meriter Hospital, 202 S. Park Street, Madison, WI, 53715, USA.
Kai WangShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. wangcn@yahoo.com.ORCID 0000-0002-0995-9774
Jing ZhengDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, PAB1 UnityPoint Health-Meriter Hospital, 202 S. Park Street, Madison, WI, 53715, USA. jzheng@wisc.edu.ORCID 0000-0002-2224-2372
University of Wisconsin–Madison · USShanghai First Maternity and Infant Hospital · CNGuangdong Medical College · CN

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Preeclampsia-Induced Fetal Endothelial Dysfunction in Obese Pregnancy: Novel roles of miR192-5pR03HD100778 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI ZHOU, CHI · 2020 to 2021
$154k
NCATS NIH HHS UL1 TR002373NICHD NIH HHS R03 HD100778
6 · The paper itself

Abstract

Preeclampsia (PE) is a hypertensive pregnancy, which is a leading cause of maternal and fetal morbidity and mortality during pregnancy. L-Tryptophan (Trp) is an essential amino acid, which can be metabolized into various biologically active metabolites. However, the levels of many circulating Trp-metabolites in human normotensive pregnancies (NT) and PE are undetermined. This study quantified the levels of Trp-metabolites in maternal and umbilical vein sera from women with NT and PE. Paired maternal and umbilical blood samples were collected from singleton pregnant patients. Twenty-five Trp-metabolites were measured in serum samples using liquid chromatography with tandem mass spectrometry. The effects of L-kynurenine (Kyn) and indole-3-lactic acid (ILA), on function of human umbilical vein endothelial cells (HUVECs), were also determined. Twenty Trp-metabolites were detected. The levels of 9 Trp-metabolites including Kyn and ILA were higher (P < 0.05) in umbilical vein than maternal serum, whereas 2 (5-hydroxy-L-tryptophan and serotonin) were lower (P < 0.05) in umbilical vein compared to maternal serum. PE significantly (P < 0.05) elevated ILA levels in maternal and umbilical vein sera. Kyn dose-dependently decreased (P < 0.05) cell viability. Kyn and ILA dose- and time-dependently (P < 0.05) increased monolayer integrity in HUVECs. These data suggest that these Trp-metabolites are important in regulating endothelial function during pregnancy, and the elevated ILA in PE may antagonize increased endothelial permeability occurring in PE.

Indexed as

Pre-EclampsiaTryptophanFemaleFetusHumansHuman Umbilical Vein Endothelial CellsKynureninePregnancyKynurenineTryptophanCirculationsEndothelial functionPreeclampsiaPregnancyTryptophan-metabolites

Identifiers

PMID34622427
PMCPMC8917071
OpenAlexW3203185577

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.