Evidence map›Paper›PMID 34622377›Full record

SynthesisJournal of thrombosis and thrombolysis2022

Efficacy and safety of low intensity vitamin K antagonists in Western and East-Asian patients with left-sided mechanical heart valves.

Arjun K Pandey, Ke Xu, Li Zhang, Saurabh Gupta, John Eikelboom, Renato D Lopes, Mark Crowther, Emilie P Belley-Côté, Richard P Whitlock

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of thrombosis and thrombolysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Arjun K PandeyMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.
Ke XuDepartment of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Li ZhangBanner University Medical Center, Tucson, USA.
Saurabh GuptaDivision of Cardiac Surgery, Department of Surgery, McMaster University, Hamilton, Canada.
John EikelboomDepartment of Medicine, McMaster University, Hamilton, Canada.
Renato D LopesDuke Clinical Research Institute, Durham, USA.
Mark CrowtherDepartment of Medicine, McMaster University, Hamilton, Canada.
Emilie P Belley-CôtéPopulation Health Research Institute, 237 Barton Street East, Hamilton, ON, Canada.
Richard P WhitlockDivision of Cardiac Surgery, Department of Surgery, McMaster University, Hamilton, Canada. Richard.Whitlock@phri.ca.ORCID http://orcid.org/0000-0002-6863-5884
McMaster University · CAPopulation Health Research Institute · CABanner - University Medical Center Tucson · USDuke University · USShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The optimal INR target in patients with mechanical heart valves is unclear. Higher INR targets are often used in Western compared with East Asian countries. The objective of this systematic review and meta-analysis was to summarize the evidence for the efficacy and safety of lower versus higher INR targets in Western and East Asian left-sided mechanical heart valve patients. We searched Western databases including Cochrane CENTRAL, Medline, and Embase as well as Chinese databases including SinoMed, CNKI, and Wanfang Data in addition to grey literature for Randomized Controlled Trials (RCTs) and observational studies. We pooled risk ratios (RRs) using random-effects model. Low and high INR targets were defined by the individual studies. We identified nine RCTs, including six Western (n = 5496) and three East Asian (n = 209) trials, and 17 observational studies, including two Western (n = 3199) and 15 East Asian (n = 5485) studies. In the RCTs, lower compared with higher targets were associated with similar rates of thromboembolism (2.4 vs. 2.3%; RR: 1.14, 95% CI 0.82, 1.60, I

Indexed as

AnticoagulantsThromboembolismFibrinolytic AgentsHeart ValvesHemorrhageHumansVitamin KAnticoagulantsFibrinolytic AgentsVitamin KINRMechanical heart valvesWarfarin

Identifiers

PMID34622377
OpenAlexW3204020281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.