Evidence map›Paper›PMID 34622251›Full record

ArticleProceedings of the 2014 6th International Advanced Research Workshop on In Silico Oncology and Cancer Investigation : the CHIC Project Workshop (IARWISOCI) : Athens, Greece, 3-4 November 2014. International Advanced Research Workshop on...2014

Machine Learning Predictions of Cancer Driver Mutations.

E Joseph Jordan, Ravi Radhakrishnan

Abstract read
In one paragraph

Article in Proceedings of the 2014 6th International Advanced Research Workshop on In Silico Oncology and Cancer Investigation : the CHIC Project Workshop (IARWISOCI) : Athens, Greece, 3-4 November 2014. International Advanced Research Workshop on..., 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

E Joseph JordanThe University of Pennsylvania Biochemistry and Molecular Biophysics Graduate Group, PA 19104 USA.
Ravi RadhakrishnanThe University of Pennsylvania Departments of Bioengineering, Chemical and Biomolecular Engineering, Biochemistry and Biophysics, PA 19104 USA.

Funding

PSOC@Penn Education and OutreachU54CA193417 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, DENNIS E. · 2015 to 2020
$10.5M
Bridging multiple scales in modeling targeted drug nanocarrier deliveryU01EB016027 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI ECKMANN, DAVID M, RADHAKRISHNAN, RAVI · 2013 to 2017
$2.7M
NCI NIH HHS U54 CA193417NIBIB NIH HHS U01 EB016027
6 · The paper itself

Abstract

A method to predict the activation status of kinase domain mutations in cancer is presented. This method, which makes use of the machine learning technique support vector machines (SVM), has applications to cancer treatment, as well as numerous other diseases that involve kinase misregulation.

Identifiers

PMID34622251
PMCPMC8494176

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.