Evidence map›Paper›PMID 34622236›Full record

ArticleCell reports. Medicine2021

Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma.

Jaime L Chao, Michael Korzinkin, Alex Zhavoronkov, Ivan V Ozerov, Matthew T Walker, Kathleen Higgins, Mark W Lingen, Evgeny Izumchenko, Peter A Savage

Open access · goldAbstract read
In one paragraph

Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
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  7. Article
  8. Article
  9. Article
  10. Review
  11. The Role of IL-17 in the Pathogenesis of Oral Squamous Cell Carcinoma.International journal of molecular sciences · 2023
    Review
  12. Review
  13. Article
  14. The impact ofJournal of Cancer · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jaime L ChaoDepartment of Pathology, University of Chicago, Chicago, IL 60637, USA.
Michael KorzinkinInsilico Medicine Hong Kong, Ltd., Pak Shek Kok, Hong Kong.
Alex ZhavoronkovInsilico Medicine Hong Kong, Ltd., Pak Shek Kok, Hong Kong.
Ivan V OzerovInsilico Medicine Hong Kong, Ltd., Pak Shek Kok, Hong Kong.
Matthew T WalkerDepartment of Pathology, University of Chicago, Chicago, IL 60637, USA.
Kathleen HigginsDepartment of Pathology, University of Chicago, Chicago, IL 60637, USA.
Mark W LingenDepartment of Pathology, University of Chicago, Chicago, IL 60637, USA.
Evgeny IzumchenkoDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
Peter A SavageDepartment of Pathology, University of Chicago, Chicago, IL 60637, USA.
University of Chicago · US

Funding

INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7M
Delineating chromatin-related gene expression signatures as a function of HNSCC progressionR01DE027809 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI GAYKALOVA, DARIA A, IZUMCHENKO, EVGENY (EUGENE) G · 2019 to 2023
$2.6M
NIAID NIH HHS T32 AI007090NIDCR NIH HHS R01 DE027809
6 · The paper itself

Abstract

Immune suppression by CD4

Indexed as

4-Nitroquinoline-1-oxideAmino Acid SequenceAnimalsAntigens, NeoplasmCarcinogensCarcinoma, Squamous CellCD8-Positive T-LymphocytesClone CellsHumansImmune Checkpoint InhibitorsLymphocyte CountLymphocyte DepletionMiceMice, Inbred C57BLMouth NeoplasmsNeoplasm Invasiveness4-Nitroquinoline-1-oxide4-nitroquinolone-1-oxideAntigens, NeoplasmCarcinogensImmune Checkpoint InhibitorsPeptidesQuinolonescancer immunologyoral squamous cell carcinomaregulatory T cells

Identifiers

PMID34622236
PMCPMC8484691
OpenAlexW3200741223

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.