ArticleCell reports. Medicine2021
Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota.
Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 63 citations in OpenAlex.
- Fecal microbiota composition is related to brown adipose tissueJournal of endocrinological investigation · 2023Trial
- Meal-Induced Proton Density Fat Fraction andNMR in biomedicine · 2026Article
- EAT Thickness and BAT-Related Thermogenesis: Dual Imaging Phenotypes Associated with Hepatic Steatosis Severity in MASLD.Diagnostics (Basel, Switzerland) · 2026Article
- DietaryCurrent issues in molecular biology · 2026Article
- Alginate oligosaccharides prevent and treat obesity by promoting brown fat thermogenesis rather than regulating gut microbiota.Journal of advanced research · 2026Article
- Gut microbiota-immune crosstalk in childhood and adolescent obesity: mechanistic insights and therapeutic potential focused on short-chain fatty acids and emerging metabolites.Frontiers in microbiology · 2026Review
- Herbal Combination ofFood science & nutrition · 2025Article
- MASH: the nexus of metabolism, inflammation, and fibrosis.The Journal of clinical investigation · 2025Review
- Brown and beige adipose tissue-derived metabokine and lipokine inter-organ signalling in health and disease.Experimental physiology · 2025Review
- Emerging debates and resolutions in brown adipose tissue research.Cell metabolism · 2025Review
- In recent research: exosomal and molecular regulators of browning and thermogenesis in adipose tissues.Turkish journal of medical sciences · 2025Review
- CD47-mediated regulation of glucose and lipid metabolism: implications for the pathogenesis of MASLD.Frontiers in endocrinology · 2025Review
- Flavonoids and Their Role in Preventing the Development and Progression of MAFLD by Modifying the Microbiota.International journal of molecular sciences · 2024Review
- Review
- Tracers and Imaging of Fatty Acid and Energy Metabolism of Human Adipose Tissues.Physiology (Bethesda, Md.) · 2024Review
- Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseases.JHEP reports : innovation in hepatology · 2024Review
- Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis.JCI insight · 2024Article
- Xiasangju alleviate metabolic syndrome by enhancing noradrenaline biosynthesis and activating brown adipose tissue.Frontiers in pharmacology · 2024Article
- Promoting metabolic inefficiency for metabolic disease.iScience · 2023Review
- Insulin resistance and adipose tissue interactions as the cornerstone of metabolic (dysfunction)-associated fatty liver disease pathogenesis.World journal of gastroenterology · 2023Review
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Authors and funding
24 authors at 5 institutions in 1 country.
Funding
Abstract
In rodents, lower brown adipose tissue (BAT) activity is associated with greater liver steatosis and changes in the gut microbiome. However, little is known about these relationships in humans. In adults (n = 60), we assessed hepatic fat and cold-stimulated BAT activity using magnetic resonance imaging and the gut microbiota with 16S sequencing. We transplanted gnotobiotic mice with feces from humans to assess the transferability of BAT activity through the microbiota. Individuals with NAFLD (n = 29) have lower BAT activity than those without, and BAT activity is inversely related to hepatic fat content. BAT activity is not related to the characteristics of the fecal microbiota and is not transmissible through fecal transplantation to mice. Thus, low BAT activity is associated with higher hepatic fat accumulation in human adults, but this does not appear to have been mediated through the gut microbiota.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.