Evidence map›Paper›PMID 34622230›Full record

ArticleCell reports. Medicine2021

Infant gut strain persistence is associated with maternal origin, phylogeny, and traits including surface adhesion and iron acquisition.

Yue Clare Lou, Matthew R Olm, Spencer Diamond, Alexander Crits-Christoph, Brian A Firek, Robyn Baker, Michael J Morowitz, Jillian F Banfield

Abstract read
In one paragraph

Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Observational
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  14. Human microbiome acquisition and transmission.Nature reviews. Microbiology · 2025
    Review
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yue Clare LouDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Matthew R OlmDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Spencer DiamondDepartment of Earth and Planetary Science, University of California, Berkeley, CA 94709, USA.
Alexander Crits-ChristophDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Brian A FirekDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Robyn BakerDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Michael J MorowitzDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Jillian F BanfieldDepartment of Earth and Planetary Science, University of California, Berkeley, CA 94709, USA.

Funding

Population Genomic Analysis of Gut Microbial Colonization in Premature InfantsR01AI092531 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Jillian Banfield, Michael Morowitz · 2011 to 2026
$11.3M
NIAID NIH HHS R01 AI092531
6 · The paper itself

Abstract

Gut microbiome succession affects infant development. However, it remains unclear what factors promote persistence of initial bacterial colonizers in the developing gut. Here, we perform strain-resolved analyses to compare gut colonization of preterm and full-term infants throughout the first year of life and evaluate associations between strain persistence and strain origin as well as genetic potential. Analysis of fecal metagenomes collected from 13 full-term and 9 preterm infants reveals that infants' initially distinct microbiomes converge by age 1 year. Approximately 11% of early colonizers, primarily

Indexed as

Bacterial AdhesionGastrointestinal MicrobiomePhylogenyBacteriaCarbohydrate MetabolismFecesGenome, HumanHumansInfantInfant, NewbornInfant, PrematureIronMetagenomicsSiblingsIroncommunity ecologyearly-life gut colonizationInfant gut microbiomestrain-resolved metagenomics

Identifiers

PMID34622230
PMCPMC8484513

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.