Evidence map›Paper›PMID 34622199›Full record

ArticleVaccine: X2021

Multiplexed VaxArray immunoassay for rapid antigen quantification in measles and rubella vaccine manufacturing.

Jacob H Gillis, Keely N Thomas, Senthilkumar Manoharan, Mallikarjuna Panchakshari, Amber W Taylor, David F Miller, Rose T Byrne-Nash, Christine Riley, Kathy L Rowlen, Erica Dawson

Abstract read
In one paragraph

Article in Vaccine: X, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jacob H GillisInDevR Inc., Boulder, CO, USA.
Keely N ThomasInDevR Inc., Boulder, CO, USA.
Senthilkumar ManoharanBiological E. Ltd., Hyderabad, India.
Mallikarjuna PanchakshariBiological E. Ltd., Hyderabad, India.
Amber W TaylorInDevR Inc., Boulder, CO, USA.
David F MillerInDevR Inc., Boulder, CO, USA.
Rose T Byrne-NashInDevR Inc., Boulder, CO, USA.
Christine RileyInDevR Inc., Boulder, CO, USA.
Kathy L RowlenInDevR Inc., Boulder, CO, USA.
Erica DawsonInDevR Inc., Boulder, CO, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Measles-containing vaccines (MCV), specifically vaccines against measles and rubella (MR), are extremely effective and critical for the eradication of measles and rubella diseases. In developed countries, vaccination rates are high and vaccines are readily available, but continued high prevalence of both diseases in developing countries and surges in measles deaths in recent years have highlighted the need to expand vaccination efforts. To meet demand for additional vaccines at a globally affordable price, it is highly desirable to streamline vaccine production thereby reducing cost and speeding up time to delivery. MR vaccine characterization currently relies on the 50% cell culture infectious dose (CCID

Indexed as

Antigen QuantificationCCID50IdentificationMeaslesMicroarrayMR VaccineMultiplexed ImmunoassayRubellaVaccine ManufacturingVaxArray

Identifiers

PMID34622199
PMCPMC8484809

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.