ArticleiScience2021
Personalized sleep-wake patterns aligned with circadian rhythm relieve daytime sleepiness.
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Data-Driven Scheduling Strategies to Minimize Fatigue in Rotating Night-Shift Nurses.Journal of nursing management · 2026Observational
- Patterns of rest-activity rhythms from adolescence to young adulthood: a scoping review.Frontiers in sleep · 2026Review
- Preventive circadian medicine: improving health with sleep checkups.Npj biological timing and sleep · 2025Review
- Accurately predicting mood episodes in mood disorder patients using wearable sleep and circadian rhythm features.NPJ digital medicine · 2024Article
- Long-term night-shift work is associated with accelerates brain aging and worsens N3 sleep in female nurses.Sleep medicine · 2024Article
- Biomathematical modeling of fatigue due to sleep inertia.Journal of theoretical biology · 2024Article
- Association of Rest-Activity Rhythm and Risk of Developing Dementia or Mild Cognitive Impairment in the Middle-Aged and Older Population: Prospective Cohort Study.JMIR public health and surveillance · 2024Article
- Causal Association Between Subtypes of Excessive Daytime Sleepiness and Risk of Cardiovascular Diseases.Journal of the American Heart Association · 2023Article
- Method to determine whether sleep phenotypes are driven by endogenous circadian rhythms or environmental light by combining longitudinal data and personalised mathematical models.PLoS computational biology · 2023Article
- Chemotherapy delivery time affects treatment outcomes of female patients with diffuse large B cell lymphoma.JCI insight · 2023Article
- A jerk-based algorithm ACCEL for the accurate classification of sleep-wake states from arm acceleration.iScience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shift workers and many other groups experience irregular sleep-wake patterns. This can induce excessive daytime sleepiness that decreases productivity and elevates the risk of accidents. However, the degree of daytime sleepiness is not correlated with standard sleep parameters like total sleep time, suggesting other factors are involved. Here, we analyze real-world sleep-wake patterns of shift workers measured with wearables by developing a computational package that simulates homeostatic sleep pressure - physiological need for sleep - and the circadian rhythm. This reveals that shift workers who align sleep-wake patterns with their circadian rhythm have lower daytime sleepiness, even if they sleep less. The alignment, quantified by the sleep parameter, circadian sleep sufficiency, can be increased by dynamically adjusting daily sleep durations according to varying bedtimes. Our computational package provides flexible and personalized real-time sleep-wake patterns for individuals to reduce their daytime sleepiness and could be used with wearables to develop smart alarms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.