ArticleiScience2021
Bridging large-scale cortical networks: Integrative and function-specific hubs in the thalamus.
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Thalamic nuclei volumes across psychiatric and neurological disorders: a multi-site magnetic resonance imaging study.Translational psychiatry · 2026Article
- Shared white matter connectome-based correlates of self-reproach, response failure, spatial planning, and resilience in patients with subthreshold depression: a graph theory approach.Scientific reports · 2026Article
- Failure to integrate: Connector hub dysfunction in major depressive disorder.NeuroImage. Clinical · 2026Article
- Disrupted thalamocortical functional connectivity and canonical resting-state network integration in posttraumatic stress disorder.NeuroImage. Clinical · 2026Article
- Neuroendocrine-vascular interaction is associated with thalamocortical disorganization and cognitive decline in perimenopausal hypertension.Frontiers in medicine · 2026Article
- Predicting sugar-sweetened beverage intake from the brain and known risk factors in adolescents.Physiology & behavior · 2025Article
- Progressive Changes Between Thalamic Nuclei and Cortical Networks Across Stimulus-Response Learning.Human brain mapping · 2025Article
- The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques.bioRxiv : the preprint server for biology · 2025Article
- A model of thalamo-cortical interaction for incremental binding in mental contour-tracing.PLoS computational biology · 2025Article
- Emergent Aspects of the Integration of Sensory and Motor Functions.Brain sciences · 2025Review
- Volumetric Assessment and Graph Theoretical Analysis of Thalamic Nuclei in Essential Tremor.Brain and behavior · 2025Article
- The network-based underpinnings of persisting symptoms after concussion: a multimodal neuroimaging meta-analysis.Nature. Mental health · 2025Article
- Frequency-specific segregation and integration of human cerebral cortex: An intrinsic functional atlas.iScience · 2024Article
- The impact of the human thalamus on brain-wide information processing.Nature reviews. Neuroscience · 2023Review
- Involvement of cerebellar and subcortical connector hubs in schizophrenia.NeuroImage. Clinical · 2022Article
- Connectivity impairment of cerebellar and sensorimotor connector hubs in Parkinson's disease.Brain communications · 2022Article
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The thalamus is critical for the brain's integrative hub functions; however, the localization and characterization of the different thalamic hubs remain unclear. Using a voxel-level network measure called functional connectivity overlap ratio (FCOR), we examined the thalamus' association with large-scale resting-state networks (RSNs) to elucidate its connector hub roles. Connections to the core-neurocognitive networks were localized in the anterior and medial parts, such as the anteroventral and mediodorsal nuclei areas. Regions functionally connected to the sensorimotor network were distinctively located around the lateral pulvinar nucleus but to a limited extent. Prominent connector hubs include the anteroventral, ventral lateral, and mediodorsal nuclei with functional connections to multiple RSNs. These findings suggest that the thalamus, with extensive connections to most of the RSNs, is well placed as a critical integrative functional hub and could play an important role for functional integration facilitating brain functions associated with primary processing and higher cognition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.