ArticleiScience2021
The gut microbiota modulates brain network connectivity under physiological conditions and after acute brain ischemia.
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Gut microbiota-mediated neuroinflammation following stroke: mechanisms and intervention strategies.Journal of translational medicine · 2026Review
- Maternal docosahexaenoic acid supplementation shapes offspring gut microbiota to modulate the gut-brain axis in a sow-piglet model.Frontiers in nutrition · 2026Article
- Role of the gut-brain axis in neurological diseases: Molecular connections and therapeutic implications (Review).International journal of molecular medicine · 2025Review
- Deficiency of intestinal alkaline phosphatase affects behavior and microglia activity in mice.Brain, behavior, and immunity · 2025Article
- Article
- Role of gut microbiota in ischemic stroke: A narrative review of human and animal studies.Neuroprotection (Chichester, England) · 2024Review
- Therapeutic approaches targeting the gut microbiota in ischemic stroke: current advances and future directions.Bioscience of microbiota, food and health · 2024Review
- Article
- Article
- Functional hyperconnectivity related to brain disease: maladaptive process or element of resilience?Neural regeneration research · 2023Article
- Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease.Amino acids · 2022Review
- Perspectives on Understanding Aberrant Brain Networks in Epilepsy.Frontiers in network physiology · 2022Article
- Monitoring Neuronal Network Disturbances of Brain Diseases: A Preclinical MRI Approach in the Rodent Brain.Frontiers in cellular neuroscience · 2021Review
- Intestinal microbiota modulates neuroinflammatory response and brain injury after neonatal hypoxia-ischemia.Gut microbesArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiome has been implicated as a key regulator of brain function in health and disease. But the impact of gut microbiota on functional brain connectivity is unknown. We used resting-state functional magnetic resonance imaging in germ-free and normally colonized mice under naive conditions and after ischemic stroke. We observed a strong, brain-wide increase of functional connectivity in germ-free animals. Graph theoretical analysis revealed significant higher values in germ-free animals, indicating a stronger and denser global network but with less structural organization. Breakdown of network function after stroke equally affected germ-free and colonized mice. Results from histological analyses showed changes in dendritic spine densities, as well as an immature microglial phenotype, indicating impaired microglia-neuron interaction in germ-free mice as potential cause of this phenomenon. These results demonstrate the substantial impact of bacterial colonization on brain-wide function and extend our so far mainly (sub) cellular understanding of the gut-brain axis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.