Evidence map›Paper›PMID 34622023›Full record

ArticleHealth science reports2021

The association of oxidative stress biomarkers with type 2 diabetes mellitus: A systematic review and meta-analysis.

Sujan Banik, Antara Ghosh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Health science reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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  6. Research progress on PANoptosis in diabetic cardiomyopathy.Journal of physiology and biochemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sujan BanikDepartment of Pharmacy Noakhali Science and Technology University Noakhali Bangladesh.ORCID https://orcid.org/0000-0001-9639-6836
Antara GhoshDepartment of Pharmacy Noakhali Science and Technology University Noakhali Bangladesh.ORCID https://orcid.org/0000-0003-2349-1642
Noakhali Science and Technology University · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsOxidative stress plays a major role in the development of type 2 diabetes mellitus (T2DM). However, there were controversial outcomes in the literature between the association of oxidative stress biomarkers and T2DM. The purpose of this systematic review and meta-analysis was to critically examine the association of oxidative stress biomarkers with T2DM.

methodsWe systematically searched different electronic databases including PubMed/Medline, EMBASE, ScienceDirect, Web of Science, and Cochrane Library to find the relevant studies up to May 2021. The pooled standard mean difference (SMD) with a 95% confidence interval (CI) was used to define the variation between the study groups.

resultsA total of 22 case-control studies with 2853 subjects (1667 diabetic patients and 1186 healthy controls) were found to be eligible for this meta-analysis. The pooled results of meta-analysis showed a significant difference in the levels malondialdehyde (SMD [95% CI]: 2.27 [1.62, 2.91]), nitric oxide (SMD [95% CI]: 1.40 [0.00, 2.81]), glutathione (SMD [95% CI]: -1.76 [-2.94, -0.59]), and total antioxidant status (SMD [95% CI]: -1.40 [-2.28, -0.51]) between the patient group and healthy subjects, whereas no significant difference was observed in the superoxide dismutase levels (SMD [95% CI]: -1.20 [-2.55, 0.15]) and glutathione peroxidase levels (SMD [95% CI]: 0.07 [-2.80, 2.94]).

conclusionThe present analysis suggests that oxidative stress might have a potential role in the pathogenesis of T2DM in humans. However, further studies should be needed to elucidate the possible mechanism and strengthen this evidence.

Indexed as

antioxidantmalondialdehydemeta‐analysisoxidative stresstype 2 diabetes mellitus

Identifiers

PMID34622023
PMCPMC8485598
OpenAlexW3156018043

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.