ArticleWorld journal of clinical cases2021
Clinical metagenomic sequencing for rapid diagnosis of pneumonia and meningitis caused by
Article in World journal of clinical cases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 11 citations in OpenAlex.
- Current status and challenges in the diagnosis and treatment of psittacosis.Infectious diseases & immunity · 2026Review
- Chlamydia psittaci Meningitis, Chile, 2023.Emerging infectious diseases · 2026Article
- Pneumonia with BALF Detection ofInfection and drug resistance · 2026Article
- Non-invasive management of severe chlamydia psittaci pneumonia presenting with hypoxemia and diarrhea: a case report.Frontiers in medicine · 2026Article
- Epidemiological characteristics and environmental surveillance of human psittacosis in Lishui City, Zhejiang Province, China (2021-2024).Frontiers in microbiology · 2026Article
- Clinical application of metagenomic next-generation sequencing in the diagnosis of severe pneumonia pathogens.Frontiers in cellular and infection microbiology · 2025Article
- Clinical characteristics ofFrontiers in medicine · 2025Article
- Analysis and Perception ofInfection and drug resistance · 2024Article
- Early and rapid diagnosis ofFrontiers in medicine · 2024Article
- Exploring multidrug-resistant Klebsiella pneumoniae antimicrobial resistance mechanisms through whole genome sequencing analysis.BMC microbiology · 2023Article
- Clinical Features, Treatment, and Outcome of Psittacosis Pneumonia: A Multicenter Study.Open forum infectious diseases · 2023Article
- Metagenomic surveillance and comparative genomic analysis ofFrontiers in microbiology · 2023Article
- Atypical pneumonia caused by Chlamydia psittaci during the COVID-19 pandemic.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Application of Metagenomic Next-Generation Sequencing in the Etiological Diagnosis of Infective Endocarditis During the Perioperative Period of Cardiac Surgery: A Prospective Cohort Study.Frontiers in cardiovascular medicine · 2022Article
- Direct Metagenomic Diagnosis of Community-Acquired Meningitis: State of the Art.Frontiers in microbiology · 2022Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background
aimTo demonstrate that mNGS represents a valuable tool for rapid, sensitive, and accurate pathogen detection including
methodsFour cases of psittacosis pneumonia and one case of pediatric psittacosis meningitis were diagnosed between December 2019 and May 2020 using mNGS at Changzhou Second People's Hospital affiliated to Nanjing Medical University. Patients' clinical characteristics, manifestations, and treatment histories were retrospectively evaluated.
resultsAll five patients had a history of exposure to wild (psittacine or other birds) or domesticated birds (chickens). All patients had a high fever (> 39℃) and three of them (60%) experienced organ insufficiency during the disease. The laboratory data showed normal to slightly increased leucocyte and neutrophil counts, and elevated procalcitonin levels in all five cases, and very high C-reactive protein levels in psittacosis pneumonia patients. mNGS identified a potential pathogen,
conclusionThis study not only demonstrated that mNGS represents a valuable tool for rapid, sensitive, and accurate pathogen detection, but also raised public health concerns over
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