Evidence map›Paper›PMID 34621590›Full record

ArticleSurgical neurology international2021

The impact of subcaudate tractotomy on delusions and hallucinations in psychotic patients.

Osvaldo Vilela-Filho, Paulo C Ragazzo, Darianne Canêdo, Uadson S Barreto, Paulo M Oliveira, Lissa C Goulart, Manoel D Reis, Telma M Campos

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical neurology international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07671261 (Deep Brain Stimulation for Treatment-Refractory Schizophrenia), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07671261 narecruitingnot on this mapstarted 2025, after this paper: background citation

Deep Brain Stimulation for Treatment-Refractory Schizophrenia: Individualized Target Selection and Efficacy

TypeinterventionalSponsorRuijin HospitalRan2025 to 2028Enrolled46ConditionsSchizophrenia Disorders, Schizo Affective DisorderArmsSEEG implantation, Deep brain stimulation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Osvaldo Vilela-FilhoDepartment of Stereotactic and Functional Neurosurgery, Goiânia Neurological Institute, Goiânia, Brazil.
Paulo C RagazzoDepartment of Neurology, Goiânia Neurological Institute, Goiânia, Brazil.
Darianne CanêdoDepartment of Neurosciences, Medical School, Pontifical Catholic University of Goiás, Goiânia, Brazil.
Uadson S BarretoDepartment of Neurosciences, Medical School, Pontifical Catholic University of Goiás, Goiânia, Brazil.
Paulo M OliveiraDepartment of Psychiatry, Goiânia Neurological Institute, Goiânia, Brazil.
Lissa C GoulartDepartment of Surgery, Division of Neurosurgery, Federal University of Goiás; Goiânia, Brazil.
Manoel D ReisDepartment of Psychiatry, Goiânia Neurological Institute, Goiânia, Brazil.
Telma M CamposDepartment of Psychiatry, Goiânia Neurological Institute, Goiânia, Brazil.
Fundação de Apoio a Pesquisa do Estado de Goiás · BRPontifícia Universidade Católica de Goiás · BRInstituto de Gastroenterologia de Goiânia · BRInstituto de Olhos de Goiânia · BRUniversidade Federal de Goiás · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDelusions and hallucinations, hallmarks of the psychotic disorders, usually do not respond to surgical intervention. For many years, the surgical technique of choice for the treatment of refractory aggressiveness in psychotic patients in our Service was amygdalotomy in isolation or associated with anterior cingulotomy. No improvement of hallucinations and delusions was noticed in any of these patients. To improve the control of aggression, subcaudate tractotomy was added to the previous surgical protocol. The main goal of the present study was to investigate the impact of this modified surgical approach on delusions and hallucinations.

methodsRetrospective analysis of the medical records of psychotic patients presenting with treatment-resistant aggressiveness, delusions, and hallucinations submitted to bilateral subcaudate tractotomy + bilateral anterior cingulotomy + bilateral amygdalotomy in our institution.

resultsFive patients, all males, with ages ranging from 25 to 65 years, followed up by a mean of 45.6 months (17-72 months), fulfilled the inclusion criteria. Delusions and hallucinations were abolished in four of them.

conclusionThese results suggest that the key element for relieving these symptoms was the subcaudate tractotomy and that the orbitofrontal and ventromedial prefrontal cortices play an important role in the genesis of hallucinatory and delusional symptoms of schizophrenia and other psychoses.

Indexed as

DelusionsHallucinationsPsychosisPsychosurgerySchizophreniaSubcaudate tractotomy

Identifiers

PMID34621590
PMCPMC8492415
OpenAlexW3200014177

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.