Evidence map›Paper›PMID 34621530›Full record

ArticleJournal of virus eradication2021

Persistent HIV-1 transcription in CD4

M Vignoles, V Andrade, M Noguera, C Brander, C Mavian, M Salemi, R Paredes, M Sharkey, M Stevenson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virus eradication, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

M VignolesDepartment of Medicine, University of Miami Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
V AndradeDepartment of Medicine, University of Miami Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
M NogueraInstitut de Recerca de La SIDA - IrsiCaixa Hospital Universitari Germans Trias i Pujol, Crta. De Canyet S/n, Planta 2a, 08916, Badalona, Catalonia, Spain.
C BranderInstitut de Recerca de La SIDA - IrsiCaixa Hospital Universitari Germans Trias i Pujol, Crta. De Canyet S/n, Planta 2a, 08916, Badalona, Catalonia, Spain.
C MavianEmerging Pathogens Institute, Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
M SalemiEmerging Pathogens Institute, Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
R ParedesInstitut de Recerca de La SIDA - IrsiCaixa Hospital Universitari Germans Trias i Pujol, Crta. De Canyet S/n, Planta 2a, 08916, Badalona, Catalonia, Spain.
M SharkeyDepartment of Medicine, University of Miami Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
M StevensonDepartment of Medicine, University of Miami Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
University of Miami · USHospital Universitari Germans Trias i Pujol · ESUniversity of Florida · USIrsiCaixa · ES

Funding

Viral evolution in peropheral macrophages and brain during progression to AIDSR01NS063897 · NINDS · UNIVERSITY OF FLORIDA · PI SALEMI, MARCO · 2009 to 2021
$7.0M
Revealing HIV-1 persistence in myeloid cell reservoirsR01MH116701 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Mario Stevenson · 2018 to 2026
$4.0M
NIMH NIH HHS R01 MH116701NINDS NIH HHS R01 NS063897
6 · The paper itself

Abstract

HIV-1 is able to persist in the face of potent antiretroviral therapy (ART). A number of strategies are being explored to allow ART-free viral remission or viral eradication. In order to gauge the progress of these strategies, assays with which to measure viral reservoir size and activity are needed. In a large percentage of aviremic individuals on suppressive ART, viral transcripts can be detected in peripheral blood CD4

Indexed as

Cell-associated RNAHIV-1Viral reservoir surrogate

Identifiers

PMID34621530
PMCPMC8479831
OpenAlexW3201167021

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.