Evidence map›Paper›PMID 34621299›Full record

ArticleFrontiers in genetics2021

HIF-1α Pulmonary Phenotype Wide Association Study Unveils a Link to Inflammatory Airway Conditions.

Jelte Kelchtermans, Xiao Chang, Michael E March, Frank Mentch, Patrick M A Sleiman, Hakon Hakonarson

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jelte KelchtermansPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Xiao ChangThe Center of Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Michael E MarchThe Center of Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Frank MentchThe Center of Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Patrick M A SleimanThe Center of Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Hakon HakonarsonPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

NRSA Training CoreTL1TR001880 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$10.0M
NCATS NIH HHS TL1 TR001880
6 · The paper itself

Abstract

Despite experimental data linking HIF-1α dysfunction to inflammatory airway conditions, the effect of single nucleotide polymorphisms within the

Indexed as

airwaybronchiolitisHIF1Ahypoxia inducible factorinflammationphenotyperhinitisSNP

Identifiers

PMID34621299
PMCPMC8490729
OpenAlexW3201304863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.