Evidence map›Paper›PMID 34621189›Full record

ReviewFrontiers in physiology2021

Irisin, Energy Homeostasis and Male Reproduction.

Pallav Sengupta, Sulagna Dutta, Ivan Rolland Karkada, Roland Eghoghosoa Akhigbe, Suresh V Chinni

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Observational
  8. Review
  9. Review
  10. Article
  11. Article
  12. Endocrinopathies and Male Infertility.Life (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Pallav SenguptaPhysiology Unit, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Kuala Lumpur, Malaysia.
Sulagna DuttaDepartment of Oral Biology and Biomedical Sciences, Faculty of Dentistry, MAHSA University, Kuala Lumpur, Malaysia.
Ivan Rolland KarkadaPhysiology Unit, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Kuala Lumpur, Malaysia.
Roland Eghoghosoa AkhigbeDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Suresh V ChinniDepartment of Biotechnology, Faculty of Applied Sciences, AIMST University, Bedong, Malaysia.
Mahsa University · MYAIMST University · MYLadoke Akintola University of Technology · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irisin is a novel skeletal muscle- and adipose tissue-secreted peptide. It is conventionally regarded as an adipomyokine and is a cleaved fragment of Fibronectin type III domain-containing protein 5 (FNDC5). It is involved in the browning of white adipose tissue, glucose tolerance, and reversing of metabolic disruptions. Fertility is closely linked to energy metabolism and the endocrine function of the adipose tissue. Moreover, there is established association between obesity and male infertility. Irisin bears strong therapeutic promise in obesity and its associated disorders, as well as shown to improve male reproductive functions. Thus, irisin is a molecule of great interest in exploring the amelioration of metabolic syndrome or obesity-induced male infertility. In this review we aim to enumerate the most significant aspects of irisin actions and discuss its involvement in energy homeostasis and male reproduction. Though current and future research on irisin is very promiscuous, a number of clarifications are still needed to reveal its full potential as a significant medicinal target in several human diseases including male infertility.

Indexed as

energy metabolismirisinmale infertilitymetabolic syndromereproduction

Identifiers

PMID34621189
PMCPMC8490744
OpenAlexW3200910429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.