Evidence map›Paper›PMID 34621182›Full record

ArticleFrontiers in physiology2021

MEDEX 2015: Prophylactic Effects of Positive Expiratory Pressure in Trekkers at Very High Altitude.

Thomas Rupp, Claire Maufrais, Guillaume Walther, François Esteve, Jamie Hugo Macdonald, Pierre Bouzat, Samuel Verges

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07148674 (Efficacy of Positive Expiratory Pressure on Acute Mountain Sickness, a Pilot Crossover Trial at 6000 Meters), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07148674 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Positive Expiratory Pressure on Acute Mountain Sickness, a Pilot Crossover Trial at 6000 Meters

TypeinterventionalSponsorBiALP - Alpine, Disaster and Wilderness MedicineRan2025 to 2025Enrolled3ConditionsAcute Mountain Sickness (AMS)ArmsPositive Expiratory Pressure (10cmH2O) in hypobaric hypoxia
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Change in pulmonary artery pressure upon acute exposure to high altitude: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 2 countries.

Thomas RuppInter-University Laboratory of Human Movement Science (LIBM), University Savoie Mont Blanc, Chambéry, France.
Claire MaufraisLaboratoire de Pharm-Ecologie Cardiorespiratoire (LAPEC EA4278), Avignon University, Avignon, France.
Guillaume WaltherLaboratoire de Pharm-Ecologie Cardiorespiratoire (LAPEC EA4278), Avignon University, Avignon, France.
François EsteveRSRM EA7442, ID17-ESRF, Grenoble Alpes University, Grenoble, France.
Jamie Hugo MacdonaldExtremes Research Group, School of Sport, Health and Exercise Sciences, Bangor University, Bangor, United Kingdom.
Pierre BouzatPôle Anesthésie Réanimation, Grenoble Alpes University Hospital, Grenoble, France.
Samuel VergesHP2 Laboratory, INSERM, Grenoble Alpes University, Grenoble, France.
Bangor University · GBGrenoble Institute of Neurosciences · FRInserm · FRLaboratoire de Physique du Rayonnement et de la Lumière · FRUniversité d'Avignon et des Pays de Vaucluse · FRUniversité Grenoble Alpes · FRUniversité Savoie Mont Blanc · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

altitude illnesscardiac functioncerebral perfusionextreme environmenthypoxiamedical expeditionPEP breathingtissue oxygenation

Identifiers

PMID34621182
PMCPMC8490760
OpenAlexW3201235966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.