Evidence map›Paper›PMID 34621145›Full record

ArticleContrast media & molecular imaging2021

Preclinical Molecular PET-CT Imaging Targeting CDCP1 in Colorectal Cancer.

Tahleesa J Cuda, Yaowu He, Thomas Kryza, Tashbib Khan, Brian W Tse, Kamil A Sokolowski, Cheng Liu, Nicholas Lyons, Madeline Gough, Cameron E Snell and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contrast media & molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Tahleesa J CudaFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.ORCID 0000-0003-0531-8862
Yaowu HeMater Research Institute The University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia.
Thomas KryzaMater Research Institute The University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia.
Tashbib KhanMater Research Institute The University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia.
Brian W TsePreclinical Imaging Core Facility, Translational Research Institute, Woolloongabba, QLD, Australia.ORCID 0000-0002-5982-8369
Kamil A SokolowskiPreclinical Imaging Core Facility, Translational Research Institute, Woolloongabba, QLD, Australia.
Cheng LiuFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Nicholas LyonsFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Madeline GoughMater Research Institute The University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia.
Cameron E SnellMater Research Institute The University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia.
David K WyldFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Stephen RoseCommonwealth Scientific and Industrial Research Organisation, Herston, QLD, Australia.
Andrew D RiddellRedcliffe Hospital, Metro North Hospital and Health Service, Brisbane, QLD, Australia.
Andrew R L StevensonFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Paul A ThomasFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
David A ClarkFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Simon PuttickCommonwealth Scientific and Industrial Research Organisation, Herston, QLD, Australia.
John D HooperMater Research Institute The University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia.ORCID 0000-0003-1054-8486
Translational Research Institute · AUThe University of Queensland · AUCommonwealth Scientific and Industrial Research Organisation · AURedcliffe Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is the third most common malignancy in the world, with 22% of patients presenting with metastatic disease and a further 50% destined to develop metastasis. Molecular imaging uses antigen-specific ligands conjugated to radionuclides to detect and characterise primary cancer and metastases. Expression of the cell surface protein CDCP1 is increased in CRC, and here we sought to assess whether it is a suitable molecular imaging target for the detection of this cancer. CDCP1 expression was assessed in CRC cell lines and a patient-derived xenograft to identify models suitable for evaluation of radio-labelled 10D7, a CDCP1-targeted, high-affinity monoclonal antibody, for preclinical molecular imaging. Positron emission tomography-computed tomography was used to compare zirconium-89 (

Indexed as

Positron Emission Tomography Computed TomographyAnimalsAntigens, NeoplasmCell Adhesion MoleculesColorectal NeoplasmsGene Expression Regulation, NeoplasticHCT116 CellsHeterograftsHumansLigandsMiceRadioisotopesZirconiumAntigens, NeoplasmCDCP1 protein, humanCell Adhesion MoleculesLigandsRadioisotopesZirconiumZirconium-89

Identifiers

PMID34621145
PMCPMC8455202
OpenAlexW3200457634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.