Evidence map›Paper›PMID 34621133›Full record

ArticleCancer management and research2021

Concomitant Pulmonary Tuberculosis Impair Survival in Advanced Epidermal Growth Factor Receptor (EGFR) Mutant Lung Adenocarcinoma Patients Receiving EGFR-Tyrosine Kinase Inhibitor.

Yalin Xie, Ning Su, Wei Zhou, An Lei, Xiang Li, Weiwei Li, Zhan Huang, Wenchang Cen, Jinxing Hu

Open access · goldAbstract read
In one paragraph

Article in Cancer management and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yalin XieDepartment of Oncology, Guangzhou Chest Hospital, Guangzhou, People's Republic of China.
Ning SuDepartment of Oncology, Guangzhou Chest Hospital, Guangzhou, People's Republic of China.
Wei ZhouDepartment of Pathology, Guangzhou Chest Hospital, Guangzhou, People's Republic of China.
An LeiDepartment of Oncology, Guangzhou Chest Hospital, Guangzhou, People's Republic of China.
Xiang LiDepartment of Pharmacy, Guangzhou Chest Hospital, Guangzhou, People's Republic of China.
Weiwei LiDepartment of Medical Business, Amoy Diagnostics Co., Ltd., Xiamen, People's Republic of China.
Zhan HuangDepartment of Medical Business, Amoy Diagnostics Co., Ltd., Xiamen, People's Republic of China.
Wenchang CenDepartment of Oncology, Guangzhou Chest Hospital, Guangzhou, People's Republic of China.
Jinxing HuDepartment of Tuberculosis, Guangzhou Chest Hospital, Guangzhou, People's Republic of China.
Guangzhou Chest Hospital · CNDian Diagnostics (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveLimited studies have clearly demonstrated the effect of EGFR-TKI in the treatment of

methodsClinicopathologic data of 1448 LUAD patients harboring

resultsAfter EGFR-TKIs treatment, the objective response rate (58.14% vs 47.62%) as well as disease control rate (97.67% vs 85.71%) were higher in the non-PTB group than in the PTB group, but there was no statistical difference. In the survival analysis, both the median progression-free survival (7.47 months vs 11.77 months,

conclusionLUAD patients with concomitant PTB have a poor response to EGFR-TKI treatment, especially in terms of survival outcome.

Indexed as

advanced lung adenocarcinomaEGFR mutationEGFR-tyrosine kinase inhibitorsprognosispulmonary tuberculosis

Identifiers

PMID34621133
PMCPMC8491869
OpenAlexW3202297970

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.