Evidence map›Paper›PMID 34621111›Full record

ArticleBioinformation2020

QSAR modeling and docking analysis of D2 receptor with known olanzapine derivatives.

Kiran Bhargava, Prahlad Kishore Seth, Kamlesh Kumar Pant, Rakesh Kumar Dixit, Vivek Agarwal, Kamal Kumar Sawlanid, Rajendra Nath

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kiran BhargavaKing George's Medical University Erstwhile CSMMU, Lucknow, UP, India.
Prahlad Kishore SethBiotech Park, Lucknow, UP, India.
Kamlesh Kumar PantKing George's Medical University Erstwhile CSMMU, Lucknow, UP, India.
Rakesh Kumar DixitKing George's Medical University Erstwhile CSMMU, Lucknow, UP, India.
Vivek AgarwalKing George's Medical University Erstwhile CSMMU, Lucknow, UP, India.
Kamal Kumar SawlanidKing George's Medical University Erstwhile CSMMU, Lucknow, UP, India.
Rajendra NathKing George's Medical University Erstwhile CSMMU, Lucknow, UP, India.
King George's Medical University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dopamine (D2) receptors are known drug targets for various antipsychotics used in Schizophrenia. Therefore, it is of interest to analyze the binding features of D2 receptors with known olanzapine derivatives for further consideration using molecular docking and QSAR analysis. A 2D QSAR model was built using energy-based descriptors generated by docking as independent variable and known Ki value of Olanzapine derivatives with D2 Receptor as dependent variable. QSAR model provided coefficient of determination of r2 of 0.7 in multiple linear regression analysis. The predictive performance of QSAR model was assessed using different cross-validation procedures. Thus, data shows that a ligand-receptor binding interaction for D2 Receptor using a QSAR model is promising approach to design novel and potent inhibitors of D2 Receptor.

Indexed as

Antipsychotic agentsD2 receptorOlanzapine derivativesQSARSchizophrenia

Identifiers

PMID34621111
PMCPMC8457016
OpenAlexW3047024577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.